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Substance Name: Lefetamine hydrochloride [JAN]
RN: 14148-99-3
UNII: XYT5RKF8JA
InChIKey: VKIHKZMKDNVEIK-PKLMIRHRSA-N

Molecular Formula

  • C16-H19-N.Cl-H

Molecular Weight

  • 261.794
 

Classification Codes

Classification Code

  • Drug / Therapeutic Agent

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Lefetamine hydrochloride [JAN]

Synonyms

  • (-)-N,N-Dimethyl-1,2-diphenylethylamine hydrochloride
  • l-1,2-Diphenyl-1-dimethylaminoethane hydrochloride
  • Lefetamine HCl
  • Lefetamine hydrochloride
  • SPA
  • SPA (analgesic)
  • UNII-XYT5RKF8JA

Systematic Names

  • Benzeneethanamine, N,N-dimethyl-alpha-phenyl-, hydrochloride, (R)-, (9CI)
  • Ethylamine, N,N-dimethyl-1,2-diphenyl-, hydrochloride, (R) (-)-

Superlist Names

  • DEA No. 1635
  • SPA

Registry Numbers

CAS Registry Number

  • 14148-99-3

FDA UNII

  • XYT5RKF8JA

System Generated Number

  • 0014148993

Molecular Formulas

Molecular Formula

  • C16-H19-N.Cl-H

Molecular Formula Fragments

  • C16-H19-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H19N.ClH/c1-17(2)16(15-11-7-4-8-12-15)13-14-9-5-3-6-10-14;/h3-12,16H,13H2,1-2H3;1H/t16-;/m1./s1

InChIKey

VKIHKZMKDNVEIK-PKLMIRHRSA-N

Smiles

c1([C@@H](Cc2ccccc2)[NH+](C)C)ccccc1.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 123mg/kg (123mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56, Pg. 514, 1960.
mouse LD50 intravenous 32600ug/kg (32.6mg/kg)   Drugs of the Future. Vol. 2, Pg. 39, 1977.
mouse LD50 oral 440mg/kg (440mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56, Pg. 522, 1960.
mouse LD50 subcutaneous 210mg/kg (210mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56, Pg. 522, 1960.
rat LD50 intraperitoneal 100mg/kg (100mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56, Pg. 522, 1960.
rat LD50 oral 300mg/kg (300mg/kg)   Drugs of the Future. Vol. 2, Pg. 39, 1977.
rat LD50 subcutaneous 148mg/kg (148mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 221, Pg. 105, 1976.