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Substance Name: Zolimomab aritox [USAN:INN]
RN: 141483-72-9
UNII: 2C1ZT922TD

Note

  • Composed of the ricin A chain which is conjugated to monoclonal antibodies that recognize the CD5 antigen; used in preventing & treating graft-vs-host disease.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Drug / Therapeutic Agent
  • Monoclonal Antibody (Antithrombotic)
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Names and Synonyms

Name of Substance

  • Zolimomab aritox
  • Zolimomab aritox [USAN:INN]

Synonyms

  • H65-RTA
  • Immunoglobulin G 1 (mouse monoclonal H65-RTA anti-human antigen CD 5 heavy chain), disulfide with mouse monoclonal H65-RTA light chain, dimer, disulfide with ricin (castor-oil plant A-chain protein moiety)
  • Immunoglobulin G 1 (mouse monoclonal H65-RTA anti-human antigen CD 5 heavy chain), disulfide with mouse monoclonal H65-RTA light chain, dimer, disulfide with ricin (castor-oil plant A-chain protein moiety). Molecular weight is approximately 210,000 daltons
  • Monoclonal antibody (antitrombotic)
  • Orthozyme CD5 Plus
  • Orthzyme CD5plus
  • UNII-2C1ZT922TD
  • Zolimomab aritox

Systematic Names

  • Immunoglobulin G 1 (mouse monoclonal H65-RTA anti-human antigen CD 5 heavy chain), disulfide with mouse monoclonal H65-RTA light chain, dimer, disulfide with ricin (castor-oil plant A-chain protein moiety)
  • Immunoglobulin G 1 (mouse monoclonal H65-RTA anti-human antigen CD5 heavy chain), disulfide with mouse monoclonal H65-rta light chain, dimer, disulfide with ricin(castor oil plant A-chain protein moiety)
  • Immunoglobulin G 1(mouse monoclonal H65-RTA anti-human antigen CD5 heavy chain), disulfide with mouse monoclonal H65-RTA light chain, dimer, disulfide with ricin (castor-oil plant A-chain protein moiety)

Registry Numbers

CAS Registry Number

  • 141483-72-9

FDA UNII

  • 2C1ZT922TD

System Generated Number

  • 0141483729

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 intravenous 60mg/kg (60mg/kg) CARDIAC: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Fundamental and Applied Toxicology. Vol. 26, Pg. 75, 1995.