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Substance Name: Monosodium glutamate
RN: 142-47-2
UNII: C3C196L9FG
InChIKey: LPUQAYUQRXPFSQ-DFWYDOINSA-M

Note

  • One of the FLAVORING AGENTS used to impart a meat-like flavor. Medically it has been used to reduce blood ammonia levels in ammoniacal azotemia, therapy of hepatic coma, in psychosis, and INTELLECTUAL DISABILITY.

Molecular Formula

  • C5-H9-N-O4.Na

Molecular Weight

  • 169.1112
 

Classification Codes

  • Food Additives
  • Human Data
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Results Name

  • Monosodium glutamate

Name of Substance

  • Glutamic acid, monosodium salt
  • Monosodium glutamate
  • Sodium glutamate

MeSH Heading

  • Sodium glutamate

Synonyms

  • Accent
  • Accent (food additive)
  • AI3-18393
  • Ajinomoto
  • Ancoma
  • CCRIS 3625
  • Chinese seasoning
  • EC 205-538-1
  • EINECS 205-538-1
  • FEMA No. 2756
  • Glutacyl
  • Glutamat sodny
  • Glutamat sodny [Czech]
  • Glutamate monosodium salt
  • Glutamate Sodium
  • Glutamate Sodium [JAN]
  • Glutamic acid, L-, sodium salt
  • Glutamic acid, monosodium salt
  • Glutammato monosodico
  • Glutammato monosodico [Italian]
  • Glutavene
  • HSDB 580
  • L(+) Sodium glutamate
  • L-Glutamic acid sodium salt
  • L-Glutamic acid, sodium salt (VAN)
  • Monosodioglutammato
  • Monosodioglutammato [Italian]
  • Monosodium glutamate
  • Monosodium glutamate anhydrous
  • Monosodium L-glutamate
  • MSG
  • Natrium L-hydrogenglutamat
  • Natriumglutaminat
  • Natriumglutaminat [German]
  • NSC 135529
  • RL-50
  • Sodium glutamate
  • Sodium glutamate (VAN)
  • Sodium hydrogen glutamate
  • Sodium L-glutamate
  • Sodium L-glutamate (VAN)
  • UNII-C3C196L9FG
  • Vetsin
  • Zest

Systematic Names

  • Glutamic acid, sodium salt
  • L-Glutamic acid, monosodium salt
  • L-Glutamic acid, sodium salt (1:1)
  • Sodium hydrogen glutamate

Superlist Names

  • Glutamic acid, monosodium salt, L-
  • Glutamic acid, sodium salt
  • Monosodium glutamate

Registry Numbers

CAS Registry Number

  • 142-47-2

FDA UNII

  • C3C196L9FG

Other Registry Numbers

  • 116268-41-8
  • 51959-41-2
  • 56974-54-0

System Generated Number

  • 0000142472

Molecular Formulas

Molecular Formula

  • C5-H9-N-O4.Na

Molecular Formula Fragments

  • C5-H9-N-O4
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1

InChIKey

LPUQAYUQRXPFSQ-DFWYDOINSA-M

Smiles

[C@H](CCC(=O)O)(C(=O)[O-])N.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 subcutaneous 8gm/kg (8000mg/kg)   Personal Communication from A.G. Ebert, International Glutamate Technical Committee, 85 Walnu St., Watertown, MA 02172, Nov. 19, 1973Vol. 19NOV1973,
guinea pig LD50 intraperitoneal 15gm/kg (15000mg/kg)   FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 424, 1974.
human TDLo intravenous 714ug/kg (0.714mg/kg) BEHAVIORAL: HEADACHE Science. Vol. 163, Pg. 826, 1969.
human TDLo oral 43mg/kg (43mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Hygiene and Sanitation Vol. 36(9), Pg. 364, 1971.
man TDLo oral 3571ug/kg (3.571mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Lancet. Vol. 1, Pg. 988, 1987.
mouse LD50 intraperitoneal 3800mg/kg (3800mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 227, Pg. 214, 1955.
mouse LD50 intravenous 30gm/kg (30000mg/kg)   FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 424, 1974.
mouse LD50 oral 11400mg/kg (11400mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 227, Pg. 214, 1955.
mouse LD50 subcutaneous 8200mg/kg (8200mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 433, 1978.
rat LD50 intraperitoneal 4253mg/kg (4253mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TETANY
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie. Vol. 300, Pg. 97, 1955.
rat LD50 intravenous 3300mg/kg (3300mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 433, 1978.
rat LD50 oral 16600mg/kg (16600mg/kg)   Farmaco, Edizione Pratica. Vol. 27, Pg. 19, 1972.
rat LD50 subcutaneous 5580mg/kg (5580mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 433, 1978.
women TDLo oral 50mg/kg (50mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA New England Journal of Medicine. Vol. 305, Pg. 1154, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -7.060 (none)   EST
Water Solubility 3.85E+05 mg/L 25 EXP
Vapor Pressure 3.70E-14 mm Hg 25 EST
Atmospheric OH Rate Constant 3.99E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.