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Substance Name: Propanidid [USAN:INN:BAN]
RN: 1421-14-3
UNII: AO82L471NS
InChIKey: KEJXLQUPYHWCNM-UHFFFAOYSA-N

Note

  • An intravenous anesthetic that has been used for rapid induction of anesthesia and for maintenance of anesthesia of short duration. (From Martindale, The Extra Pharmacopoeia, 30th ed, p918)

Molecular Formula

  • C18-H27-N-O5

Molecular Weight

  • 337.413
 

Classification Codes

  • Anesthetic (Intravenous)
  • Anesthetics
  • Anesthetics, General
  • Anesthetics, Intravenous
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Propanidid
  • Propanidid [USAN:INN:BAN]

MeSH Heading

  • Propanidid

Synonyms

  • (3-Methoxy-4-((N,N-diethylcarbamido)methoxy)phenyl)acetic acid n-propyl ester
  • (4-((Diethylcarbamoyl)methoxy)-3-methoxyphenyl)acetic acid propyl ester
  • (p-((Diethylcarbamoyl)methoxy)-3-methoxyphenyl)acetic acid propyl ester
  • 13245 R. P.
  • 2180 TH
  • 4-(2-(Diethylamino)-2-oxoethoxy)-3-methoxybenzeneacetic acid propyl ester
  • Acetic acid, (p-((diethylcarbamoyl)methoxy)-3-methoxyphenyl)-, propyl ester
  • BAY 1420
  • Bayer 1420
  • Benzeneacetic acid, 4-(2-(diethylamino)-2-oxoethoxy)-3-methoxy-, propyl ester
  • BRN 2952046
  • EINECS 215-822-7
  • Epontol
  • Fabantol
  • Fabontal
  • FBA 1420
  • Propanidid
  • Propanidide
  • Propanidide [INN-French]
  • Propanidido
  • Propanidido [INN-Spanish]
  • Propanididum
  • Propanididum [INN-Latin]
  • Propantan
  • Propyl 4-((diethylcarbamoyl)methoxy)-3-methoxyphenyl acetate
  • Propyl {4-((diethylcarbamoyl)methoxy)-3-methoxyphenyl}acetate
  • Propyl(4-((diethylcarbamoyl)methoxy)-3-methoxyphenyl)acetate
  • Sombrevin
  • TH-2180
  • UNII-AO82L471NS
  • WH 5668

Systematic Names

  • Acetic acid, (4-((diethylcarbamoyl)methoxy)-3-methoxyphenyl)-, propyl ester
  • Benzeneacetic acid, 4-(2-(diethylamino)-2-oxoethoxy)-3-methoxy-, propyl ester
  • Propanidid

Registry Numbers

CAS Registry Number

  • 1421-14-3

FDA UNII

  • AO82L471NS

System Generated Number

  • 0001421143

Structure Descriptors

InChI

1S/C18H27NO5/c1-5-10-23-18(21)12-14-8-9-15(16(11-14)22-4)24-13-17(20)19(6-2)7-3/h8-9,11H,5-7,10,12-13H2,1-4H3

InChIKey

KEJXLQUPYHWCNM-UHFFFAOYSA-N

Smiles

c1(c(cc(CC(OCCC)=O)cc1)OC)OCC(N(CC)CC)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 80mg/kg (80mg/kg)   Acta Anaesthesiologica Scandinavica, Supplementum. Vol. 17, Pg. 21, 1965.
dog LD50 intravenous 80mg/kg (80mg/kg)   Acta Anaesthesiologica Scandinavica, Supplementum. Vol. 17, Pg. 21, 1965.
human TDLo intravenous 5mg/kg (5mg/kg) BEHAVIORAL: GENERAL ANESTHETIC British Journal of Anesthesia. Vol. 45, Pg. 1097, 1973.
mouse LD50 intravenous 113mg/kg (113mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 845, 1980.
rabbit LD50 intravenous 75mg/kg (75mg/kg)   Acta Anaesthesiologica Scandinavica, Supplementum. Vol. 17, Pg. 21, 1965.
rat LD50 intravenous 81mg/kg (81mg/kg)   Acta Anaesthesiologica Scandinavica, Supplementum. Vol. 17, Pg. 21, 1965.
rat LD50 oral > 10gm/kg (10000mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
log P (octanol-water) 2.370 (none)   EST
Atmospheric OH Rate Constant 6.24E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.