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Substance Name: Amidephrine mesylate [USAN]
RN: 1421-68-7
UNII: S3IG39T94B
InChIKey: INSXAGGBFMXUIH-UHFFFAOYSA-N

Classification Codes

  • Adrenergic
  • Adrenergic Agents
  • Drug / Therapeutic Agent
  • Skin / Eye Irritant

Molecular Formula

  • C10-H16-N2-O3-S.C-H4-O3-S

Molecular Weight

  • 340.419
 
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Names and Synonyms

Name of Substance

  • Amidefrine mesilate [INN]
  • Amidephrine mesylate
  • Amidephrine mesylate [USAN]
  • Amidephrine monoethanesulfonate

Synonyms

  • (2-Methylamine-1-hydroxyethyl)methanesulfonanilide methanesulfonate
  • 3'-(1-Hydroxy-2-(methylamino)ethyl)methanesulfonanilide methanesulfonate
  • 3'-(1-Hydroxy-2-(methylamino)ethyl)methanesulfonanilide monomethanesulfonate (salt)
  • 3'-(2-(Methylamino)-l-hydroxyethyl)methanesulfonanilide methanesulfonate
  • 5190
  • Amideferini mesilas
  • Amideferini mesilas [INN-Latin]
  • Amidefrine mesilate
  • Amidefrine mesylate
  • Amidefrini mesilas
  • Amidefrini mesilas [INN-Spanish]
  • Amidefrini mesylas
  • Amidephrine mesylate
  • Amidephrine monomethanesulfonate
  • Dricol
  • Fentrinol
  • Mesilate d'amidefrine
  • Mesilate d'amidefrine [INN-French]
  • Mesylate d'amideferine
  • Methanesulfonamide, N-(3-(1-hydroxy-2-(methylamino)ethyl)phenyl)-, monomethanesulfonate (salt)
  • Methanesulfonamide, N-(3-(1-hydroxy-2-(methylamino)ethyl)phenyl)-, monomethanesulfonate salt
  • Methanesulfonanilide, 3'-(1-hydroxy-2-(methylamino)ethyl)-, methanesulfonate
  • MJ 5190
  • Nalde
  • Product 5190
  • UNII-S3IG39T94B

Systematic Names

  • 3-(2-Methylamino-1-hydroxyethyl)methanesulfonanilide methanesulfonate
  • Methanesulfonamide, N-(3-(1-hydroxy-2-(methylamino)ethyl)phenyl)-, monomethanesulfonate (salt)
  • Methanesulfonanilide, 3'-(1-hydroxy-2-(methylamino)ethyl)-, monomethanesulfonate (salt)

Registry Numbers

CAS Registry Number

  • 1421-68-7

FDA UNII

  • S3IG39T94B

System Generated Number

  • 0001421687

Molecular Formulas

Molecular Formula

  • C10-H16-N2-O3-S.C-H4-O3-S

Molecular Formula Fragments

  • C-H4-O3-S
  • C10-H16-N2-O3-S
  • COMPONENT

Structure Descriptors

InChI

1S/C10H16N2O3S.CH4O3S/c1-11-7-10(13)8-4-3-5-9(6-8)12-16(2,14)15;1-5(2,3)4/h3-6,10-13H,7H2,1-2H3;1H3,(H,2,3,4)

InChIKey

INSXAGGBFMXUIH-UHFFFAOYSA-N

Smiles

c1(cc(ccc1)NS(C)(=O)=O)[C@@H](CNC)O.S(C)(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 2mg/kg (2mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Toxicology and Applied Pharmacology. Vol. 23, Pg. 589, 1972.
dog LD50 intraperitoneal 1400ug/kg (1.4mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Toxicology and Applied Pharmacology. Vol. 23, Pg. 589, 1972.
dog LD50 intravenous 1400ug/kg (1.4mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicology and Applied Pharmacology. Vol. 23, Pg. 589, 1972.
mouse LD50 intraperitoneal 780mg/kg (780mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicology and Applied Pharmacology. Vol. 23, Pg. 589, 1972.
mouse LD50 intravenous 190mg/kg (190mg/kg)   International Journal of Neuropharmacology. Vol. 4, Pg. 219, 1965.
mouse LD50 oral 2284mg/kg (2284mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicology and Applied Pharmacology. Vol. 23, Pg. 589, 1972.
mouse LD50 subcutaneous 1990mg/kg (1990mg/kg)   International Journal of Neuropharmacology. Vol. 4, Pg. 219, 1965.
rabbit LD50 intradermal 7500ug/kg (7.5mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Toxicology and Applied Pharmacology. Vol. 23, Pg. 589, 1972.
rabbit LD50 oral 12mg/kg (12mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Toxicology and Applied Pharmacology. Vol. 23, Pg. 589, 1972.
rat LD50 intraperitoneal 5mg/kg (5mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 23, Pg. 589, 1972.
rat LD50 oral 13mg/kg (13mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicology and Applied Pharmacology. Vol. 23, Pg. 589, 1972.