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Substance Name: Osimertinib [USAN]
RN: 1421373-65-0
UNII: 3C06JJ0Z2O
InChIKey: DUYJMQONPNNFPI-UHFFFAOYSA-N

Note

  • An EGFR tyrosine kinase inhibitor.

    NCI: EGFR inhibitor AZD9291. An orally available, irreversible, third-generation, mutant-selective epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, AZD9291 selectively and covalently binds to and inhibits the activity of the mutant forms of EGFR, including the T790M EGFR mutant form, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase overexpressed or mutated in many types of cancers, plays a key role in tumor cell proliferation and tumor vascularization. As AZD9291 inhibits T790M, a secondarily acquired resistance mutation, this agent may have therapeutic benefits in tumors with T790M-mediated resistance. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced as compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.(NCI Thesaurus)

Molecular Formula

  • C28-H33-N7-O2

Molecular Weight

  • 499.6157
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors
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Names and Synonyms

Name of Substance

  • AZD-9291
  • Mereletinib [INN]
  • Osimertinib [USAN]

Synonyms

  • 2-Propenamide, N-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-
  • AZD 9291
  • AZD-9291
  • AZD9291
  • Mereletinib
  • Osimertinib
  • Tagrisso
  • UNII-3C06JJ0Z2O

Registry Numbers

CAS Registry Number

  • 1421373-65-0

FDA UNII

  • 3C06JJ0Z2O

Other Registry Number

  • 1610419-47-0

System Generated Number

  • 1421373650

Structure Descriptors

InChI

1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)

InChIKey

DUYJMQONPNNFPI-UHFFFAOYSA-N

Smiles

Cn1cc(c2c1cccc2)c3ccnc(n3)Nc4cc(c(cc4OC)N(C)CCN(C)C)NC(=O)C=C