Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Protionamide [INN:BAN:DCF]
RN: 14222-60-7
UNII: 76YOO33643
InChIKey: VRDIULHPQTYCLN-UHFFFAOYSA-N

Note

  • Antitubercular agent similar in action and side effects to ETHIONAMIDE. It is used mostly in combination with other agents.

Molecular Formula

  • C9-H12-N2-S

Molecular Weight

  • 180.2738
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antitubercular Agents
  • Drug / Therapeutic Agent
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Prothionamide
  • Protionamide [INN:BAN:DCF]

MeSH Heading

  • Prothionamide

Synonyms

  • 1321 TH
  • 2-Propyl-4-pyridinecarbothioamide
  • 2-Propyl-4-thiocarbamoylpyridine
  • 2-Propyl-thioisonicotinamide
  • 2-Propylisonicotinylthioamide
  • 5-22-02-00376 (Beilstein Handbook Reference)
  • 9778 R.P.
  • BRN 0118164
  • EINECS 238-093-7
  • Ektebin
  • Peteha
  • Prothionamide
  • Prothionamidum
  • Protionamid
  • Protionamida
  • Protionamida [INN-Spanish]
  • Protionamide
  • Protionamidum
  • Protionamidum [INN-Latin]
  • Protionizina
  • RP 9778
  • Tebeform
  • TH 1321
  • TH-1321
  • Trevintix
  • Tuberex
  • UNII-76YOO33643

Systematic Names

  • 2-Propylthioisonicotinamide
  • 4-Pyridinecarbothioamide, 2-propyl- (9CI)
  • Isonicotinamide, 2-propylthio-
  • Protionamide

Registry Numbers

CAS Registry Number

  • 14222-60-7

FDA UNII

  • 76YOO33643

System Generated Number

  • 0014222607

Structure Descriptors

InChI

1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)

InChIKey

VRDIULHPQTYCLN-UHFFFAOYSA-N

Smiles

CCCc1cc(ccn1)C(=S)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral > 1gm/kg (1000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Farmakologiya i Toksikologiya Vol. 38, Pg. 471, 1975.
mouse LD50 oral 1gm/kg (1000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Farmakologiya i Toksikologiya Vol. 38, Pg. 471, 1975.
mouse LD50 subcutaneous 660mg/kg (660mg/kg)   Drugs in Japan Vol. 6, Pg. 726, 1982.
rat LD50 oral 1320mg/kg (1320mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: MUSCLE WEAKNESS
Farmakologiya i Toksikologiya Vol. 38, Pg. 471, 1975.
rat LD50 subcutaneous 760mg/kg (760mg/kg)   Drugs in Japan Vol. 6, Pg. 726, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 136.7 deg C   EXP
log P (octanol-water) 2.020 (none)   EST
Atmospheric OH Rate Constant 2.55E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.