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Substance Name: Acetazolamide sodium [JAN]
RN: 1424-27-7
UNII: 429ZT169UH
InChIKey: MRSXAJAOWWFZJJ-UHFFFAOYSA-M

Note

  • One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Molecular Formulas

  • C4-H5-N4-Na-O3-S2
  • C4-H5-N4-O3-S2.Na

Molecular Weight

  • 244.2305
 

Classification Codes

  • Carbonic Anhydrase Inhibitor
  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Acetazolamide sodium [JAN]

Synonyms

  • Acetamide, N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-, monosodium salt
  • Acetazolamide sodium
  • Acetazolamide sodium salt
  • Diamox
  • N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide monosodium salt
  • Sodium acetazolamide
  • UNII-429ZT169UH

Systematic Names

  • Acetamide, N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-, monosodium salt
  • Acetamide, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-, monosodium salt

Registry Numbers

CAS Registry Number

  • 1424-27-7

FDA UNII

  • 429ZT169UH

Related Registry Number

  • 59-66-5 (Parent)

System Generated Number

  • 0001424277

Molecular Formulas

Molecular Formulas

  • C4-H5-N4-Na-O3-S2
  • C4-H5-N4-O3-S2.Na

Molecular Formula Fragments

  • C4-H5-N4-O3-S2
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C4H6N4O3S2.Na/c1-2(9)6-3-7-8-4(12-3)13(5,10)11;/h1H3,(H3,5,6,7,9,10,11);/q;+1/p-1

InChIKey

MRSXAJAOWWFZJJ-UHFFFAOYSA-M

Smiles

CC(=O)Nc1nnc(s1)S(=O)(=O)[NH-].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 2gm/kg (2000mg/kg)   Bulletin of the Johns Hopkins Hospital. Vol. 95, Pg. 199, 1954.
guinea pig LDLo subcutaneous 1500mg/kg (1500mg/kg)   Bulletin of the Johns Hopkins Hospital. Vol. 95, Pg. 199, 1954.
mouse LD50 intravenous 3gm/kg (3000mg/kg)   Bulletin of the Johns Hopkins Hospital. Vol. 95, Pg. 199, 1954.
rat LD oral > 1gm/kg (1000mg/kg)   Bulletin of the Johns Hopkins Hospital. Vol. 95, Pg. 199, 1954.
rat LDLo subcutaneous 3gm/kg (3000mg/kg)   Bulletin of the Johns Hopkins Hospital. Vol. 95, Pg. 199, 1954.