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Substance Name: Bencyclane fumarate [JAN]
RN: 14286-84-1
UNII: OZN2MG334O
InChIKey: LSTKNZAMFRGXCG-WLHGVMLRSA-N

Note

  • A vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels.

Molecular Formula

  • C19-H31-N-O.C4-H4-O4

Molecular Weight

  • 405.531
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Bencyclane fumarate
  • Bencyclane fumarate [JAN]

Synonyms

  • 1-Benzyl-1-(3'-dimethylaminopropoxy)cycloheptane fumarate
  • 1-Propanamine, N,N-dimethyl-3-((1-(phenylmethyl)cycloheptyl)oxy)-, (E)-2-butenedioate (1:1)
  • 3-((1-Benzylcycloheptyl)oxy)-N,N-dimethylpropylamine fumarate
  • Angiociclan
  • Angiodel
  • Bencyclane fumarate
  • Diacyclan
  • Dilangio
  • Egyt 201
  • EINECS 238-204-9
  • Fludilat
  • Halidor
  • Hemoflux
  • Ludilat
  • N-(3-(1-Benzyl-cycloheptyl-oxy)-propyl)-N,N-dimethyl-ammonium-hydrogenfumarat
  • N-(3-(1-Benzyl-cycloheptyl-oxy)-propyl)-N,N-dimethyl-ammonium-hydrogenfumarat [German]
  • UNII-OZN2MG334O

Systematic Names

  • (3-((1-Benzylcycloheptyl)oxy)propyl)dimethylammonium hydrogen fumarate
  • 3-((1-Benzylcycloheptyl)oxy)-N,N-dimethylpropylamine fumarate
  • Propylamine, 3-((1-benzylcycloheptyl)oxy)-N,N-dimethyl-, fumarate

Registry Numbers

CAS Registry Number

  • 14286-84-1

FDA UNII

  • OZN2MG334O

System Generated Number

  • 0014286841

Molecular Formulas

Molecular Formula

  • C19-H31-N-O.C4-H4-O4

Molecular Formula Fragments

  • C19-H31-N-O
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C19H31NO.C4H4O4/c1-20(2)15-10-16-21-19(13-8-3-4-9-14-19)17-18-11-6-5-7-12-18;5-3(6)1-2-4(7)8/h5-7,11-12H,3-4,8-10,13-17H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChIKey

LSTKNZAMFRGXCG-WLHGVMLRSA-N

Smiles

C1CCCC(Cc2ccccc2)(OCCCN(C)C)CC1.C(\C=C\C(O)=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 300mg/kg (300mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1385, 1970.
mouse LD50 intramuscular 150mg/kg (150mg/kg)   Archivum Immunologiae et Therapiae Experimentalis. Vol. 15, Pg. 415, 1967.
mouse LD50 intraperitoneal 132mg/kg (132mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 383, 1972.
mouse LD50 intravenous 45mg/kg (45mg/kg)   Archivum Immunologiae et Therapiae Experimentalis. Vol. 15, Pg. 415, 1967.
mouse LD50 oral 446mg/kg (446mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 383, 1972.
mouse LD50 subcutaneous 203mg/kg (203mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 383, 1972.
rat LD50 intraperitoneal 86mg/kg (86mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 383, 1972.
rat LD50 intravenous 41mg/kg (41mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 383, 1972.
rat LD50 oral 414mg/kg (414mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 383, 1972.
rat LD50 subcutaneous 257mg/kg (257mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 383, 1972.