Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Protoveratrine A
RN: 143-57-7
UNII: XP343X1HJU
InChIKey: HYTGGNIMZXFORS-MGYKWWNKSA-N

Classification Codes

  • Agricultural Chemical
  • Drug / Therapeutic Agent
  • Insecticide
  • Natural Product

Molecular Formula

  • C41-H63-N-O14

Molecular Weight

  • 793.9417
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Protoveratrine A

Synonyms

  • 4-21-00-06845 (Beilstein Handbook Reference)
  • BRN 0077415
  • EINECS 205-602-9
  • NSC 23865
  • NSC 7526
  • Protalba
  • Protofecaterine A
  • Protoveratrin
  • Protoveratrine
  • Protoveratrine A
  • Puroverine
  • UNII-XP343X1HJU

Systematic Names

  • (3beta(S),4alpha,6alpha,7alpha,15alpha(R),16beta)-4,9-Epoxycevane-3,4,6,7,14,15,16,20-octol 6,7-diacetate 3-(2-hydroxy-2-methylbutyrate) 15-(2-methylbutyrate)
  • Cevane-3,4,6,7,14,15,16,20-octol, 4,9-epoxy-, 6,7-diacetate 3-(2-hydroxy-2-methylbutanoate) 15-(2-methylbutanoate), (3beta(S),4alpha,6alpha,7alpha,15alpha(R),16beta)- (9CI)
  • Cevane-3-beta,4-beta,6-alpha,7-alpha,14,15-alpha-16-beta,20-octol, 4,9-epoxy-, 6,7-diacetate 3-((+)-2-hydroxy-2-methylbutyrate) 15-((-)-2-methylbutyrate)
  • Cevane-3beta,4beta,6alpha,7alpha,14,15alpha,16beta,20-octol, 4,9-epoxy-, 6,7-diacetate 3-((+)-2-hydroxy-2-methylbutyrate) 15-((-)-2-methylbutyrate) (8CI)

Registry Numbers

CAS Registry Number

  • 143-57-7

FDA UNII

  • XP343X1HJU

Other Registry Numbers

  • 11016-42-5
  • 1360-61-8

System Generated Number

  • 0000143577

Structure Descriptors

InChI

1S/C41H63NO14/c1-10-20(4)34(46)55-33-28(45)27-23(18-42-17-19(3)12-13-25(42)38(27,9)49)24-16-39-32(40(24,33)50)30(53-22(6)44)29(52-21(5)43)31-36(39,7)15-14-26(41(31,51)56-39)54-35(47)37(8,48)11-2/h19-20,23-33,45,48-51H,10-18H2,1-9H3/t19-,20+,23-,24-,25-,26-,27+,28+,29-,30+,31-,32+,33-,36-,37-,38+,39+,40-,41+/m0/s1

InChIKey

HYTGGNIMZXFORS-MGYKWWNKSA-N

Smiles

CC[C@@H](C)C(=O)O[C@H]1[C@@H]([C@H]2[C@@H](CN3C[C@H](CC[C@H]3[C@@]2(C)O)C)[C@H]4[C@@]1([C@@H]5[C@@H]([C@@H]([C@H]6[C@]7([C@]5(C4)O[C@@]6([C@H](CC7)OC(=O)[C@](C)(CC)O)O)C)OC(=O)C)OC(=O)C)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo subcutaneous 500ug/kg (0.5mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 29, Pg. 440, 1892.
dog LDLo intravenous 1191ug/kg (1.191mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Journal of Pharmacology and Experimental Therapeutics. Vol. 120, Pg. 412, 1957.
dog LDLo subcutaneous 500ug/kg (0.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: NAUSEA OR VOMITING
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 29, Pg. 440, 1892.
frog LD50 subcutaneous 4500ug/kg (4.5mg/kg) CARDIAC: OTHER CHANGES

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

GASTROINTESTINAL: OTHER CHANGES
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 189, Pg. 397, 1938.
mouse LD50 intraperitoneal 200ug/kg (0.2mg/kg)   Journal of Agricultural and Food Chemistry. Vol. 39, Pg. 1875, 1991.
mouse LD50 intravenous 31ug/kg (0.031mg/kg)   Cesko-Slovenska Farmacie. Vol. 10, Pg. 413, 1961.
mouse LD50 subcutaneous 290ug/kg (0.29mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 89, 1955.
rabbit LD50 intravenous 23500ng/kg (0.0235mg/kg)   Annales Pharmaceutiques Francaises. Vol. 14, Pg. 783, 1956.
rabbit LD50 subcutaneous 250ug/kg (0.25mg/kg)   Annales Pharmaceutiques Francaises. Vol. 14, Pg. 783, 1956.
rat LD50 oral 5mg/kg (5mg/kg) GASTROINTESTINAL: OTHER CHANGES

CARDIAC: OTHER CHANGES
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 189, Pg. 397, 1938.
rat LD50 subcutaneous 480ug/kg (0.48mg/kg)   Annales Pharmaceutiques Francaises. Vol. 14, Pg. 783, 1956.