Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Vinblastine sulfate [USAN:USP:JAN]
RN: 143-67-9
UNII: N00W22YO2B
InChIKey: KDQAABAKXDWYSZ-PNYVAJAMSA-N

Note

  • Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)

Molecular Formula

  • C46-H58-N4-O9.H2-O4-S

Molecular Weight

  • 909.061
 

Classification Codes

Classification Codes

  • Antineoplastic
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Vinblastine sulfate [USAN:USP:JAN]

Synonyms

  • 29060 LE
  • 29060-LE
  • AI3-52943
  • Belvan, VLB
  • CCRIS 2584
  • EINECS 205-606-0
  • EXAL
  • NSC 49842
  • Rozevin sulfate
  • Uniblastin
  • UNII-N00W22YO2B
  • Velban
  • Velbe
  • Velsar
  • Vinblastine 5
  • Vinblastine sulfate
  • Vincaleucoblastine sulfate
  • Vincaleukoblastine sulfate (1:1) (salt)
  • Vincaleukoblastine, sulfate
  • VLB monosulfate

Systematic Names

  • Vinblastine sulfate
  • Vinblastine sulphate
  • Vincaleukoblastine, sulfate (1:1) (salt)

Superlist Names

  • Vinblastine sulfate
  • Vinblastine sulphate

Registry Numbers

CAS Registry Number

  • 143-67-9

FDA UNII

  • N00W22YO2B

System Generated Number

  • 0000143679

Molecular Formulas

Molecular Formula

  • C46-H58-N4-O9.H2-O4-S

Molecular Formula Fragments

  • C46-H58-N4-O9
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1

InChIKey

KDQAABAKXDWYSZ-PNYVAJAMSA-N

Smiles

CC[C@@]1(C[C@H]2C[C@@](c3c(c4ccccc4[nH]3)CCN(C2)C1)(c5cc6c(cc5OC)N([C@@H]7[C@]68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)OC)O)OC(=O)C)CC)C)C(=O)OC)O.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 500ug/kg (0.5mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3713-83,
hamster LD50 intraperitoneal 4300ug/kg (4.3mg/kg)   Cancer Letters Vol. 2, Pg. 267, 1977.
human TDLo intravenous 557ug/kg (0.557mg/kg) BLOOD: LEUKOPENIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Cancer Chemotherapy Reports. Vol. 29, Pg. 111, 1963.
mouse LD50 intraperitoneal 2700ug/kg (2.7mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.
mouse LD50 intravenous 9500ug/kg (9.5mg/kg)   Cancer Research. Vol. 39, Pg. 3575, 1979.
mouse LD50 oral 423mg/kg (423mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
mouse LD50 subcutaneous 324mg/kg (324mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
rat LD50 intraperitoneal 1mg/kg (1mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3713-83,
rat LD50 intravenous 37mg/kg (37mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
rat LD50 oral 305mg/kg (305mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
rat LD50 subcutaneous 355mg/kg (355mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.