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Substance Name: Butabarbital sodium [USP]
RN: 143-81-7
UNII: 9WTD50I918
InChIKey: QORQZMBCPRBCAB-UHFFFAOYSA-M

Molecular Formula

  • C10-H16-N2-O3.Na

Molecular Weight

  • 234.2295
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Sedative-Hypnotic

Superlist Classification Code

  • DEA Schedule III
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Names and Synonyms

Name of Substance

  • Butabarbital sodium [USP]

Synonyms

  • 5-Ethyl-5-(1-methylpropyl)barbituric acid sodium salt
  • 5-sec-Butyl-5-ethylbarbituric acid sodium salt
  • Asturidon
  • Barbitab
  • Bubartal
  • Bubartal TT
  • Butabarb
  • Butabarbital
  • Butabarbital sodium
  • Butabarbitone sodium
  • Butabarpal sodium
  • Butak
  • Butalan
  • Butasaron
  • Butased
  • Butatal sodium
  • Butazem
  • Buticaps
  • Butisol sodium
  • Cambrised
  • Carrbutabarb
  • Ciprial
  • DEA No. 2100
  • EINECS 205-611-8
  • Expansatol
  • Insolat
  • Intasedol
  • Loubarb
  • Mebutal
  • Neravan
  • Noctinal
  • NSC 11778
  • Paxital
  • Paxital (VAN)
  • Prelital
  • Quiebar
  • Sarisol
  • Sarisol No. 1
  • Sarisol No. 2
  • Secbubarbital sodium
  • Secbutabarbital sodique
  • Secbutabarbital sodium
  • Secbutobarbitone sodium
  • Seda-Bute
  • Sodium 5-ethyl-5-(1-methylpropyl)barbiturate
  • Sodium 5-ethyl-5-sec-butylbarbiturate
  • Sodium 5-sec-butyl-5-ethylbarbiturate
  • Sodium butabarbital
  • Sodium butobarbitone
  • UNII-9WTD50I918

Systematic Names

  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylpropyl)-, monosodium salt
  • Barbituric acid, 5-sec-butyl-5-ethyl-, sodium salt
  • Sodium 5-(sec-butyl)-5-ethylbarbiturate

Superlist Names

  • Butabarbital sodium
  • Butibel
  • DEA No. 2100

Mixture Name

  • Butibel

Registry Numbers

CAS Registry Number

  • 143-81-7

FDA UNII

  • 9WTD50I918

System Generated Number

  • 0000143817

Molecular Formulas

Molecular Formula

  • C10-H16-N2-O3.Na

Molecular Formula Fragments

  • C10-H16-N2-O3
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C10H16N2O3.Na/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14;/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15);/q;+1/p-1

InChIKey

QORQZMBCPRBCAB-UHFFFAOYSA-M

Smiles

C1([C@@](C(N=C(N1)[O-])=O)([C@@H](CC)C)CC)=O.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 90mg/kg (90mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 254, 1944.
human LDLo oral 125mg/kg (125mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA Clinical Toxicology. Vol. 10, Pg. 327, 1977.
human TDLo oral 120mg/kg (120mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ANOREXIA (HUMAN

BEHAVIORAL: ATAXIA		 British Medical Journal. Vol. 1, Pg. 144, 1977.
mouse LD50 intraperitoneal 247mg/kg (247mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 254, 1944.
rabbit LD50 intraperitoneal 95mg/kg (95mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 254, 1944.
rabbit LD50 intravenous 91mg/kg (91mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 254, 1944.
rabbit LD50 oral 194mg/kg (194mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 254, 1944.
rat LD50 intraperitoneal 70mg/kg (70mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 254, 1944.
rat LD50 intravenous 70mg/kg (70mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 254, 1944.
rat LD50 oral 78mg/kg (78mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 254, 1944.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -2.110 (none)   EST
Water Solubility 3.33E+05 mg/L   EXP
Atmospheric OH Rate Constant 2.01E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.