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Substance Name: Dextrophan tartrate
RN: 143-98-6
UNII: NFM769433K
InChIKey: RWTWIZDKEIWLKQ-XCPWPWHNSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H23-N-O.C4-H6-O6

Molecular Weight

  • 407.46
 
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Names and Synonyms

Results Name

  • Dextrophan tartrate

Name of Substance

  • Dextrorphan tartrate

Synonyms

  • 1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol tartrate, d-
  • d-3-Hydroxy-N-methylmorphinan tartrate
  • Dextrophan tartrate
  • Dextrorphan tartrate
  • Ro 1-6794
  • UNII-NFM769433K

Systematic Name

  • Morphinan-3-ol, 17-methyl-, tartrate (1:1) (salt), (+)-

Registry Numbers

CAS Registry Number

  • 143-98-6

FDA UNII

  • NFM769433K

System Generated Number

  • 0000143986

Molecular Formulas

Molecular Formula

  • C17-H23-N-O.C4-H6-O6

Molecular Formula Fragments

  • C17-H23-N-O
  • C4-H6-O6
  • COMPONENT

Structure Descriptors

InChI

1S/C17H23NO.C4H6O6/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;5-1(3(7)8)2(6)4(9)10/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,16+,17+;1-,2-/m11/s1

InChIKey

RWTWIZDKEIWLKQ-XCPWPWHNSA-N

Smiles

c12[C@]34CCCC[C@@H]3[C@@H]([N@](C)CC4)Cc1ccc(c2)O.C([C@@H]([C@H](C(O)=O)O)O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 42mg/kg (42mg/kg)   "Synthetic Analgesics," Oxford, Pergamon Press, 1966Vol. 2, Pg. 77, 1966.
mouse LD50 oral 385mg/kg (385mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
mouse LD50 parenteral 17414ug/kg (17.414mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 145, Pg. 11, 1964.
mouse LD50 subcutaneous 350mg/kg (350mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
rabbit LD50 intravenous 27500ug/kg (27.5mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: REGIDITY
Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
rat LD50 oral 1100mg/kg (1100mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
rat LD50 subcutaneous 800mg/kg (800mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.