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Substance Name: Topoisomerase I
RN: 143180-75-0


  • DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.

Molecular Formula

  • Unspecified
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Names and Synonyms

Results Name

  • Topoisomerase I

MeSH Heading

  • DNA Topoisomerases, Type I


  • DNA topoisomerase I
  • Topoisomerase-1

Systematic Name

  • Isomerase, deoxyribonucleate topo-, I

Registry Numbers

CAS Registry Number

  • 143180-75-0

System Generated Number

  • 0143180750