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Substance Name: Cerivastatin sodium [USAN]
RN: 143201-11-0
UNII: 6Q18G1060S
InChIKey: GPUADMRJQVPIAS-QCVDVZFFSA-M

Note

  • Cerivastatin is the ((E)-( -))isomer.

Classification Codes

  • Antihyperlipidemic
  • Inhibitor (HMG-CoA Reductase)

Molecular Formula

  • C26-H34-F-N-O5.Na

Molecular Weight

  • 481.537
 
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Names and Synonyms

Name of Substance

  • Cerivastatin sodium [USAN]
  • Rivastatin

Synonyms

  • (+)-Sodium (3R,5S,6E)-7-(4-(p-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl)-3,5-dihydroxy-6-heptenoate
  • 6-Heptanoic acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-(S-(R*,S*-(E)))-, sodium salt
  • 7-(4-(4-Fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyrid-3-yl)-3,5-dihydroxy-6-heptenoate sodium salt
  • Bay w 6228
  • Baycol
  • Cerivastatin sodium
  • Lipobay
  • UNII-6Q18G1060S

Systematic Names

  • 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-, monosodium salt, (3R,5S,6E)-
  • 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-, monosodium salt, (S-(R*,S*-(E)))-

Registry Numbers

CAS Registry Number

  • 143201-11-0

FDA UNII

  • 6Q18G1060S

System Generated Number

  • 0143201110

Molecular Formulas

Molecular Formula

  • C26-H34-F-N-O5.Na

Molecular Formula Fragments

  • C26-H34-F-N-O5
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C26H34FNO5.Na/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);/q;+1/p-1/b11-10+;/t19-,20-;/m1./s1

InChIKey

GPUADMRJQVPIAS-QCVDVZFFSA-M

Smiles

[Na+].c1(C(C)C)nc(c(c(c2ccc(cc2)F)c1COC)\C=C\[C@H](C[C@H](CC(=O)[O-])O)O)C(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 32mg/kg (32mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 402, 2000.
mouse LD50 intravenous 221mg/kg (221mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 402, 2000.
mouse LD50 oral 416mg/kg (416mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 402, 2000.
rat LD50 oral 416mg/kg (416mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 402, 2000.