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Substance Name: Toborinone [USAN:INN]
RN: 143343-83-3
UNII: 1U1N0YXM99
InChIKey: BYKYPZBCMBEEGU-UHFFFAOYSA-N

Classification Codes

  • Cardiotonic
  • Cardiotonic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Phosphodiesterase Inhibitors
  • Protective Agents
  • Vasodilator Agents

Molecular Formula

  • C21-H24-N2-O5

Molecular Weight

  • 384.4296
 
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Names and Synonyms

Name of Substance

  • Toborinone [USAN:INN]

Synonyms

  • (+-)-6-(2-Hydroxy-3-(veratrylamino)propoxy)carbostyril
  • (+-)-6-(3-(((3,4-Dimethoxyphenyl)methyl)amino)-2-hydroxypropoxy)-2(1H)-quinolinone
  • 6-(3-(((3,4-Dimethoxyphenyl)methyl)amino)-2-hydroxypropoxy)-2(1H)-quinolinone
  • BRN 5455092
  • CCRIS 7932
  • OPC-18790
  • Toborinone
  • UNII-1U1N0YXM99

Systematic Names

  • (+-)-6-(2-Hydroxy-3-(veratrylamino)propoxy)carbostyril
  • 2(1H)-Quinolinone, 6-(3-(((3,4-dimethoxyphenyl)methyl)amino)-2-hydroxypropoxy)-
  • 2(1H)-Quinolinone, 6-(3-(((3,4-dimethoxyphenyl)methyl)amino)-2-hydroxypropoxy)-, (+-)-
  • Toborinone

Registry Numbers

CAS Registry Number

  • 143343-83-3

FDA UNII

  • 1U1N0YXM99

Other Registry Number

  • 128667-95-8

System Generated Number

  • 0143343833

Structure Descriptors

InChI

1S/C21H24N2O5/c1-26-19-7-3-14(9-20(19)27-2)11-22-12-16(24)13-28-17-5-6-18-15(10-17)4-8-21(25)23-18/h3-10,16,22,24H,11-13H2,1-2H3,(H,23,25)

InChIKey

BYKYPZBCMBEEGU-UHFFFAOYSA-N

Smiles

COc1ccc(CNCC(O)COc2ccc3NC(=O)C=Cc3c2)cc1OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 18, Pg. 1114, 1993.
dog LDLo intravenous 240mg/kg (240mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: MUSCLE WEAKNESS

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24, Pg. 1971, 1996.
mouse LD50 intravenous 44mg/kg (44mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24, Pg. 2007, 1996.
rat LD50 oral 1500mg/kg (1500mg/kg)   Drugs of the Future. Vol. 18, Pg. 1114, 1993.
rat LDLo intravenous 200mg/kg (200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24, Pg. 2013, 1996.