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Substance Name: Hydroquinidine
RN: 1435-55-8
UNII: 8P68XPY4HG
InChIKey: LJOQGZACKSYWCH-LHHVKLHASA-N

Note

  • Urinary quinine metabolite.

Molecular Formula

  • C20-H26-N2-O2

Molecular Weight

  • 326.4374
 

Classification Codes

  • Anti-Arrhythmia Agents
  • Autonomic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Parasympatholytics
  • Peripheral Nervous System Agents
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Names and Synonyms

Name of Substance

  • Hydroquinidine

Synonyms

  • (8R,9S)-10,11-Dihydro-6'-methoxy-9-cinchonanol
  • (9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol
  • 10,11-Dihydroquinidine
  • Dihydrochinidin
  • Dihydroquinidine
  • EINECS 215-862-5
  • Hydroconquinine
  • Hydroquinidine
  • UNII-8P68XPY4HG

Systematic Names

  • Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)- (9CI)
  • Hydroquinidine

Registry Numbers

CAS Registry Number

  • 1435-55-8

FDA UNII

  • 8P68XPY4HG

Related Registry Numbers

  • 1476-98-8 (mono-hydrochloride)
  • 1668-97-9 (mono-hydrochloride)

System Generated Number

  • 0001435558

Structure Descriptors

InChI

1S/C20H26N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h4-6,8,11,13-14,19-20,23H,3,7,9-10,12H2,1-2H3/t13-,14-,19+,20-/m0/s1

InChIKey

LJOQGZACKSYWCH-LHHVKLHASA-N

Smiles

CC[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c3ccnc4ccc(OC)cc34

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 56500ug/kg (56.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 184, 1945.
women TDLo oral 12mg/kg (12mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: HEADACHE
Clinical Toxicology. Vol. 18, Pg. 659, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 168.5 deg C   EXP
log P (octanol-water) 3.430 (none)   EST
Atmospheric OH Rate Constant 1.51E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.