Substance Name: Abciximab [USAN:INN:BAN]
RN: 143653-53-6
UNII: X85G7936GV
Note
- A Fab fragment of the chimeric monoclonal antibody 7E3 that binds to the glycoprotein IIb-IIIa receptor of human platelets, and blocks PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX, potently inhibiting PLATELET AGGREGATION. It is used in treatment of refractory unstable angina, and for prevention of ischemic complications in patients undergoing percutaneous coronary procedures such as ANGIOPLASTY; ATHERECTOMY; or stenting.
Molecular Formula
- Unspecified
Classification Codes
- Anticoagulants
- Hematologic Agents
- Monoclonal Antibody (Antithrombotic)
- Platelet Aggregation Inhibitors
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Names and Synonyms
Name of Substance
- Abciximab
- Abciximab [USAN:INN:BAN]
MeSH Heading
- Abciximab
Synonyms
- Abciximab
- c7E3
- HSDB 8179
- Immunoglobulin G1 (human-mouse monoclonal c7E3 clone p7E3VHhCgamma1 Fab fragment anti-human glycoprotein IIb/IIIa receptor), disulfide with human-mouse monoclonal c7E3 clone p7E3VkappahCkappa light chain. Molecular weight is approximately 47,600 daltons
- Immunoglobulin G1, (human-mouse monoclonal c7E3 clone p7E3VHhCgamma1 Fab fragment anti-human glycoprotein IIb/IIIa receptor), disulfide with human-mouse monoclonal c7E3 clone p7E3VkappahCkappa light chain
- ReoPro
- UNII-X85G7936GV
Systematic Name
- Immunoglobulin G, (human-mouse monoclonal c7E3 clone p7E3V(sub H)hC(sub gamma4) Fab fragment anti-human glycoprotein IIbIIIa receptor), disulfide with human-mouse monoclonal c7E3 clone p7E3V(sub kappa)hC(sub kappa) light chain
Registry Numbers
CAS Registry Number
- 143653-53-6
FDA UNII
- X85G7936GV
System Generated Number
- 0143653536
Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | intravenous | 443ug/kg/12H- (0.443mg/kg) | BLOOD: THROMBOCYTOPENIA | New Zealand Medical Journal. Vol. 113, Pg. 86, 2000. |