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Substance Name: Abciximab [USAN:INN:BAN]
RN: 143653-53-6
UNII: X85G7936GV

Note

  • A monoclonal antibody Fab fragment that blocks the platelet glycoprotein IIb/IIIa receptor & potently inhibits platelet aggregation; used in treatment of refractory unstable angina.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Anticoagulants
  • Hematologic Agents
  • Monoclonal Antibody (Antithrombotic)
  • Platelet Aggregation Inhibitors

Names and Synonyms

Name of Substance

  • Abciximab
  • Abciximab [USAN:INN:BAN]

MeSH Heading

  • Abciximab

Synonyms

  • Abciximab
  • c7E3
  • HSDB 8179
  • Immunoglobulin G1 (human-mouse monoclonal c7E3 clone p7E3VHhCgamma1 Fab fragment anti-human glycoprotein IIb/IIIa receptor), disulfide with human-mouse monoclonal c7E3 clone p7E3VkappahCkappa light chain. Molecular weight is approximately 47,600 daltons
  • Immunoglobulin G1, (human-mouse monoclonal c7E3 clone p7E3VHhCgamma1 Fab fragment anti-human glycoprotein IIb/IIIa receptor), disulfide with human-mouse monoclonal c7E3 clone p7E3VkappahCkappa light chain
  • ReoPro
  • UNII-X85G7936GV

Systematic Name

  • Immunoglobulin G, (human-mouse monoclonal c7E3 clone p7E3V(sub H)hC(sub gamma4) Fab fragment anti-human glycoprotein IIbIIIa receptor), disulfide with human-mouse monoclonal c7E3 clone p7E3V(sub kappa)hC(sub kappa) light chain

Registry Numbers

CAS Registry Number

  • 143653-53-6

FDA UNII

  • X85G7936GV

System Generated Number

  • 0143653536

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 443ug/kg/12H- (0.443mg/kg) BLOOD: THROMBOCYTOPENIA New Zealand Medical Journal. Vol. 113, Pg. 86, 2000.