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Substance Name: GYKI 53655
RN: 143692-48-2
UNII: 91HGG22IDM
InChIKey: ASLCSBBDVWPSQT-UHFFFAOYSA-N

Note

  • An AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate) receptor antagonist.

Molecular Formula

  • C19-H20-N4-O3.Cl-H

Molecular Weight

  • 388.853
 

Classification Codes

  • Drug / Therapeutic Agent
  • Excitatory Amino Acid Agents
  • Excitatory Amino Acid Antagonists
  • Neurotransmitter Agents
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Names and Synonyms

Name of Substance

  • GYKI 53655

Synonyms

  • GYKI 53655
  • UNII-91HGG22IDM

Systematic Names

  • 7H-1,3-Dioxolo(4,5-h)(2,3)benzodiazepine-7-carboxamide, 8,9-dihydro-5-(4-aminophenyl)-N,8-dimethyl-, monohydrochloride
  • GYKI 53655

Registry Numbers

CAS Registry Number

  • 143692-48-2

FDA UNII

  • 91HGG22IDM

Other Registry Number

  • 146908-67-0

System Generated Number

  • 0143692482

Molecular Formulas

Molecular Formula

  • C19-H20-N4-O3.Cl-H

Molecular Formula Fragments

  • C19-H20-N4-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H20N4O3.ClH/c1-11-7-13-8-16-17(26-10-25-16)9-15(13)18(22-23(11)19(24)21-2)12-3-5-14(20)6-4-12;/h3-6,8-9,11H,7,10,20H2,1-2H3,(H,21,24);1H

InChIKey

ASLCSBBDVWPSQT-UHFFFAOYSA-N

Smiles

c1c(ccc(c1)N)C=1c2c(C[C@@H](N(N1)C(=O)NC)C)cc1c(OCO1)c2.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 93mg/kg (93mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
United States Patent Document. Vol. #5519019,
mouse LD50 oral 97mg/kg (97mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
United States Patent Document. Vol. #5519019,