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Substance Name: Netropsin
RN: 1438-30-8
UNII: 64B3O0RD7N
InChIKey: IDBIFFKSXLYUOT-UHFFFAOYSA-N

Note

  • A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.

Molecular Formula

  • C18-H26-N10-O3

Molecular Weight

  • 430.47
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antiviral Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Natural Product
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Names and Synonyms

Name of Substance

  • Netropsin

MeSH Heading

  • Netropsin

Synonyms

  • 2814-A
  • 4-22-00-06712 (Beilstein Handbook Reference)
  • Antibiotic 1142
  • Antibiotic T-1384
  • BRN 0376913
  • CH-777-A
  • Congocidin
  • Congocidine
  • F 6
  • IA 887
  • K-117
  • Netropsin
  • NSC 3067
  • Sinanomycin
  • T 1384
  • UNII-64B3O0RD7N

Systematic Names

  • 1H-Pyrrole-2-carboxamide, 4-((((aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-
  • N,4'-Bi(pyrrole-2-carboxamide), N'-(2-carbamoylethyl)-4-((2-guanidinoacetimidoyl)amino)-1,1'-dimethyl-

Registry Numbers

CAS Registry Number

  • 1438-30-8

FDA UNII

  • 64B3O0RD7N

Other Registry Number

  • 554-32-5

Related Registry Number

  • 63770-20-7 (hydrochloride)

System Generated Number

  • 0001438308

Structure Descriptors

InChI

1S/C18H26N10O3/c1-27-9-11(6-12(27)16(30)23-4-3-14(19)20)26-17(31)13-5-10(8-28(13)2)25-15(29)7-24-18(21)22/h5-6,8-9H,3-4,7H2,1-2H3,(H3,19,20)(H,23,30)(H,25,29)(H,26,31)(H4,21,22,24)

InChIKey

IDBIFFKSXLYUOT-UHFFFAOYSA-N

Smiles

c1(NC(c2n(cc(c2)NC(CNC(N)=N)=O)C)=O)cc(n(C)c1)C(NCCC(N)=N)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 17mg/kg (17mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1180, 1978.
mouse LD50 oral 300mg/kg (300mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1180, 1978.
mouse LD50 subcutaneous 70mg/kg (70mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1180, 1978.
mouse LDLo intraperitoneal 50mg/kg (50mg/kg)   Journal of Antibiotics, Series A. Vol. 9, Pg. 102, 1956.