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Substance Name: Netropsin
RN: 1438-30-8
UNII: 64B3O0RD7N
InChIKey: IDBIFFKSXLYUOT-UHFFFAOYSA-N
Note
- A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.
Molecular Formula
- C18-H26-N10-O3
Molecular Weight
- 430.47
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antiviral Agents
- Drug / Therapeutic Agent
- Mutation Data
- Natural Product
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Names and Synonyms
Name of Substance
- Netropsin
MeSH Heading
- Netropsin
Synonyms
- 2814-A
- 4-22-00-06712 (Beilstein Handbook Reference)
- Antibiotic 1142
- Antibiotic T-1384
- BRN 0376913
- CH-777-A
- Congocidin
- Congocidine
- F 6
- IA 887
- K-117
- Netropsin
- NSC 3067
- Sinanomycin
- T 1384
- UNII-64B3O0RD7N
Systematic Names
- 1H-Pyrrole-2-carboxamide, 4-((((aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-
- N,4'-Bi(pyrrole-2-carboxamide), N'-(2-carbamoylethyl)-4-((2-guanidinoacetimidoyl)amino)-1,1'-dimethyl-
Registry Numbers
CAS Registry Number
- 1438-30-8
FDA UNII
- 64B3O0RD7N
Other Registry Number
- 554-32-5
Related Registry Number
- 63770-20-7 (hydrochloride)
System Generated Number
- 0001438308
Structure Descriptors
InChI
1S/C18H26N10O3/c1-27-9-11(6-12(27)16(30)23-4-3-14(19)20)26-17(31)13-5-10(8-28(13)2)25-15(29)7-24-18(21)22/h5-6,8-9H,3-4,7H2,1-2H3,(H3,19,20)(H,23,30)(H,25,29)(H,26,31)(H4,21,22,24)InChIKey
IDBIFFKSXLYUOT-UHFFFAOYSA-NSmiles
c1(NC(c2n(cc(c2)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 17mg/kg (17mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1180, 1978. | |
mouse | LD50 | oral | 300mg/kg (300mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1180, 1978. | |
mouse | LD50 | subcutaneous | 70mg/kg (70mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1180, 1978. | |
mouse | LDLo | intraperitoneal | 50mg/kg (50mg/kg) | Journal of Antibiotics, Series A. Vol. 9, Pg. 102, 1956. |