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Substance Name: Barbital sodium [INN:NF]
RN: 144-02-5
UNII: 275L5M93QS
InChIKey: RGHFKWPGWBFQLN-UHFFFAOYSA-M

Note

  • A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression.

Molecular Formula

  • C8-H12-N2-O3.Na

Molecular Weight

  • 206.176
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Barbital sodium salt
  • Barbital sodium [INN:NF]

Synonyms

  • 5,5-Diethylbarbituric acid sodium deriv.
  • AI3-02728
  • Barbital Na
  • Barbital sodico
  • Barbital sodico [INN-Spanish]
  • Barbital sodique
  • Barbital sodique [INN-French]
  • Barbital sodium
  • Barbital soluble
  • Barbital, sodium deriv.
  • Barbitale sodico
  • Barbitale sodico [DCIT]
  • Barbitalum natricum
  • Barbitalum natricum [INN-Latin]
  • Barbitalum-natrium
  • Barbitone sodium
  • Barbitone, sodium deriv.
  • CCRIS 3065
  • Diethylbarbiturate monosodium
  • Diethylmalonylurea sodium
  • EINECS 205-613-9
  • Embinal
  • Medinal
  • Natrinal
  • Natriumbarbitals
  • Natriumbarbitals [German]
  • Nervoseton
  • Sodium 5,5-diethylbarbiturate
  • Sodium barbital
  • Sodium barbitone
  • Sodium diethylbarbiturate
  • Sodium ethylbarbital
  • Sodium malonylurea
  • Sodium veronal
  • Soluble barbital
  • Soprinal
  • Thyalone
  • UNII-275L5M93QS
  • Veronal sodium

Systematic Names

  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-diethyl-, monosodium salt (9CI)
  • Barbital sodium
  • Barbituric acid, 5,5-diethyl-, sodium salt
  • Sodium barbital
  • Sodium derivative of 5,5-diethylbarbituric acid

Registry Numbers

CAS Registry Number

  • 144-02-5

FDA UNII

  • 275L5M93QS

System Generated Number

  • 0000144025

Molecular Formulas

Molecular Formula

  • C8-H12-N2-O3.Na

Molecular Formula Fragments

  • C8-H12-N2-O3
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C8H12N2O3.Na/c1-3-8(4-2)5(11)9-7(13)10-6(8)12;/h3-4H2,1-2H3,(H2,9,10,11,12,13);/q;+1/p-1

InChIKey

RGHFKWPGWBFQLN-UHFFFAOYSA-M

Smiles

C1(C(NC([O-])=NC1=O)=O)(CC)CC.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 400mg/kg (400mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 39, Pg. 177, 1930.
cat LDLo subcutaneous 300mg/kg (300mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 52, 1973.
dog LDLo intravenous 300mg/kg (300mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 125, 1937.
guinea pig LDLo subcutaneous 200mg/kg (200mg/kg) BEHAVIORAL: SLEEP Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 128, Pg. 678, 1938.
mouse LD50 intraperitoneal 620mg/kg (620mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 265, 1946.
mouse LD50 intravenous 830mg/kg (830mg/kg)   Toxicology and Applied Pharmacology. Vol. 27, Pg. 70, 1974.
mouse LD50 oral 800mg/kg (800mg/kg)   Toxicology and Applied Pharmacology. Vol. 27, Pg. 70, 1974.
mouse LD50 subcutaneous 700mg/kg (700mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 268, 1953.
rabbit LD50 intraperitoneal 250mg/kg (250mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 42, Pg. 253, 1931.
rabbit LDLo intravenous 400mg/kg (400mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 125, 1937.
rabbit LDLo oral 275mg/kg (275mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 42, Pg. 253, 1931.
rabbit LDLo subcutaneous 290mg/kg (290mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 31, Pg. 1, 1927.
rat LD50 intraperitoneal 300mg/kg (300mg/kg)   Anesthesiology. Vol. 17, Pg. 43, 1956.
rat LD50 intravenous 280mg/kg (280mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 135, Pg. 213, 1962.
rat LD50 oral 600mg/kg (600mg/kg)   Archives of Toxicology. Vol. 54, Pg. 275, 1983.
rat LDLo subcutaneous 300mg/kg (300mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 31, Pg. 1, 1927.