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Substance Name: Sulfacetamide [USP:INN:BAN]
RN: 144-80-9
UNII: 4965G3J0F5
InChIKey: SKIVFJLNDNKQPD-UHFFFAOYSA-N

Note

  • An anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.

Molecular Formula

  • C8-H10-N2-O3-S

Molecular Weight

  • 214.244
 

Classification Codes

  • Anti-Infective Agents
  • Anti-Infective Agents, Local
  • Anti-Infective Agents, Urinary
  • Antibacterial
  • Mutation Data
  • Renal Agents
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Sulfacetamide
  • Sulfacetamide [USP:INN:BAN]

MeSH Heading

  • Sulfacetamide

Synonyms

  • 4-14-00-02662 (Beilstein Handbook Reference)
  • A-500
  • Acetamide, N-((4-aminophenyl)sulfonyl)-
  • Acetocid
  • Acetosulfamin
  • Acetosulfamine
  • AI3-26837
  • Albamine
  • Albucid
  • Alesten
  • Bleph-10
  • Bleph-10 liquifilm
  • BRN 0981718
  • Caswell No. 808A
  • CCRIS 6273
  • EINECS 205-640-6
  • EPA Pesticide Chemical Code 077904
  • Formosulfacetamide
  • Isopto cetamide
  • N(sup 1)-Acetyl-4-aminophenylsulfonamide
  • N(sup 1)-Acetylsulfanilamide
  • N(sup1)-Acetylsulfanilamide
  • N-((4-Aminophenyl)sulfonyl)acetamide
  • N-((p-Aminophenyl)sulfonyl)acetamide
  • N-Acetyl-4-aminobenzenesulfonamide
  • N-Acetylsulfanilamide
  • N-Sulfanilylacetamide
  • N-Sulphanilylacetamide
  • NSC 63871
  • Oclucid
  • OP-Sulfa 30
  • Ophthel-S
  • p-Aminobenzenesulfonacetamide
  • p-Aminobenzenesulfonoacetamide
  • Region
  • Sebizon
  • Solfacetamide
  • Solfacetamide [DCIT]
  • Steramide
  • Sulamyd
  • Sulf-10
  • Sulfacet
  • Sulfacetamida
  • Sulfacetamida [INN-Spanish]
  • Sulfacetamide
  • Sulfacetamidum
  • Sulfacetamidum [INN-Latin]
  • Sulfacetimide
  • Sulfacyl
  • Sulfacyl (VAN)
  • Sulfacylum
  • Sulfanilacetamide
  • Sulfanilamide, N(sup 1)-acetyl-
  • Sulfanilazetamid
  • Sulfanilazetamid [German]
  • Sulphacetamide
  • Sulphacetamidum
  • Sulphasil
  • UNII-4965G3J0F5
  • Urosulfon
  • Urosulfone

Systematic Names

  • Acetamide, N-((4-aminophenyl)sulfonyl)-
  • Acetamide, N-sulfanilyl-
  • Sulfacetamide

Superlist Name

  • N-((4-Aminophenyl)sulfonyl)acetamide

Mixture Names

  • Sultrin
  • Trysul

Registry Numbers

CAS Registry Number

  • 144-80-9

FDA UNII

  • 4965G3J0F5

Related Registry Number

  • 127-56-0 (mono-hydrochloride salt, anhydrous)

System Generated Number

  • 0000144809

Structure Descriptors

InChI

1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)

InChIKey

SKIVFJLNDNKQPD-UHFFFAOYSA-N

Smiles

c1cc(S(NC(C)=O)(=O)=O)ccc1N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 8gm/kg (8000mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: REGIDITY

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Journal of Urology. Vol. 47, Pg. 183, 1942.
mouse LD50 intraperitoneal 606mg/kg (606mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Farmatsevtichnii Zhurnal Vol. (6), Pg. 26, 1987.
mouse LD50 oral 16500mg/kg (16500mg/kg)   Journal of Urology. Vol. 47, Pg. 183, 1942.
rabbit LDLo oral 5gm/kg (5000mg/kg) BEHAVIORAL: REGIDITY

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Urology. Vol. 47, Pg. 183, 1942.
rat LD50 intravenous 6600mg/kg (6600mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 367, 1950.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 183 deg C   EXP
log P (octanol-water) -0.96 (none)   EXP
Water Solubility 1.25E+04 mg/L 37 EXP
Vapor Pressure 3.57E-08 mm Hg 25 EST
Henry's Law Constant 4.84E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.86E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.