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Substance Name: Sulfamethizole [USP:INN:BAN:JAN]
RN: 144-82-1
UNII: 25W8454H16
InChIKey: VACCAVUAMIDAGB-UHFFFAOYSA-N

Note

  • A sulfathiazole antibacterial agent.

Molecular Formula

  • C9-H10-N4-O2-S2

Molecular Weight

  • 270.336
 

Classification Codes

  • Anti-Infective Agents
  • Antibacterial
  • Drug / Therapeutic Agent
  • Mutation Data
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Sulfamethizole
  • Sulfamethizole [USP:INN:BAN:JAN]

MeSH Heading

  • Sulfamethizole

Synonyms

  • 2-(p-Aminobenzenesulfonamido)-5-methylthiadiazole
  • 2-Methyl-5-sulfanilamido-1,3,4-thiadiazole
  • 2-Sulfanilamido-5-methyl-1,3,4-thiadiazole
  • 4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
  • 5-Methyl-2-sulfanilamido-1,3,4-thiadiazole
  • AI3-50149
  • Ayerlucil
  • Benzenesulfonamide, 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)-
  • CCRIS 756
  • EINECS 205-641-1
  • Famet
  • HSDB 4379
  • Lucosil
  • Methazol
  • Microsul
  • N(sup 1)-(5-Methyl-1,3,4-thiadiazol-2-yl)-sulfanilamide
  • N(sup 1)-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide
  • N1-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide
  • Proklar
  • Renasul
  • RP 2145
  • Rufol
  • Salimol
  • Solfametizolo
  • Solfametizolo [DCIT]
  • Sulfa gram
  • Sulfamethizol
  • Sulfamethizole
  • Sulfamethizolum
  • Sulfamethizolum [INN-Latin]
  • Sulfamethylthiadiazole
  • Sulfametizol
  • Sulfametizol [INN-Spanish]
  • Sulfapyelon
  • Sulfstat
  • Sulfurine
  • Sulphamethizole
  • Tetracid
  • Thidicur
  • Thiosulfil
  • Thiosulfil Forte
  • Ultrasul
  • UNII-25W8454H16
  • Urocydal
  • Urodiaton
  • Urolucosil
  • Urosulfin
  • Uroz
  • VK 53

Systematic Names

  • Benzenesulfonamide, 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)-
  • Sulfamethizole
  • Sulfanilamide, N(sup 1)-(5-methyl-1,3,4-thiadiazol-2-yl)-

Mixture Name

  • Thiosulfil-A-Forte

Registry Numbers

CAS Registry Number

  • 144-82-1

FDA UNII

  • 25W8454H16

System Generated Number

  • 0000144821

Structure Descriptors

InChI

1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14,15)8-4-2-7(10)3-5-8/h2-5H,10H2,1H3,(H,12,13)

InChIKey

VACCAVUAMIDAGB-UHFFFAOYSA-N

Smiles

Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 3668mg/kg (3668mg/kg)   Drugs in Japan Vol. 6, Pg. 388, 1982.
mouse LD50 intraperitoneal 3290mg/kg (3290mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
mouse LD50 intravenous 1820mg/kg (1820mg/kg)   Drugs in Japan Vol. 6, Pg. 388, 1982.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 388, 1982.
mouse LD50 subcutaneous 1210mg/kg (1210mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 111, 1969.
rat LD50 intramuscular 4444mg/kg (4444mg/kg)   Drugs in Japan Vol. 6, Pg. 388, 1982.
rat LD50 intravenous 2710mg/kg (2710mg/kg)   Drugs in Japan Vol. 6, Pg. 388, 1982.
rat LD50 oral 3500mg/kg (3500mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 83, Pg. 778, 1963.
rat LD50 subcutaneous > 6560mg/kg (6560mg/kg)   Drugs in Japan Vol. 6, Pg. 388, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 208 deg C   EXP
log P (octanol-water) 0.54 (none)   EXP
Water Solubility 1050 mg/L 37 EXP
Vapor Pressure 2.06E-09 mm Hg 25 EST
Henry's Law Constant 2.63E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.39E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.