Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Sulfapyridine [USP:INN:BAN]
RN: 144-83-2
UNII: Y5V2N1KE8U
InChIKey: GECHUMIMRBOMGK-UHFFFAOYSA-N

Note

  • Antibacterial, potentially toxic, used to treat certain skin diseases.

Molecular Formula

  • C11-H11-N3-O2-S

Molecular Weight

  • 249.2929
 

Classification Codes

  • Anti-Infective Agents
  • Dermatologic Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
  • Suppressant (Dermatitis Herpetiformis)
  • Tumor Data

Names and Synonyms

Name of Substance

  • Sulfapyridine
  • Sulfapyridine [USP:INN:BAN]

MeSH Heading

  • Sulfapyridine

Synonyms

  • 2-(p-Aminobenzenesulphonamido)pyridine
  • 2-Sulfanilamidopyridin
  • 2-Sulfanilamidopyridin [German]
  • 2-Sulfanilamidopyridine
  • 2-Sulfanilyl aminopyridine
  • 2-Sulfanilylaminopyridine
  • 2-Sulfapyridine
  • A-499
  • Adiplon
  • AI3-01049
  • Coccoclase
  • Dagenan
  • EC 205-642-7
  • EINECS 205-642-7
  • Eubasin
  • Eubasinum
  • Haptocil
  • M + B 693
  • M&B 693
  • M+B 693
  • N(sup 1)-2-Pyridylsulfanilamide
  • N1-2-Pyridylsulfanilamide
  • NSC 41791
  • NSC 4753
  • Piridazol
  • Plurazol
  • Pyriamid
  • Pyridazol
  • Relbapiridina
  • Ronin
  • Septipulmon
  • Solfapiridina
  • Solfapiridina [DCIT]
  • Streptosilpyridine
  • Sulfanilamide, N(sup 1)-2-pyridyl-
  • Sulfapiridina
  • Sulfapiridina [INN-Spanish]
  • Sulfapyridine
  • Sulfapyridinum
  • Sulfapyridinum [INN-Latin]
  • Sulfidin
  • Sulfidine
  • Sulphapyridine
  • Thioseptal
  • Trianon
  • UNII-Y5V2N1KE8U

Systematic Names

  • Benzenesulfonamide, 4-amino-N-2-pyridinyl-
  • Sulfanilamide, N1-2-pyridyl- (8CI)
  • Sulfapyridine

Registry Numbers

CAS Registry Number

  • 144-83-2

FDA UNII

  • Y5V2N1KE8U

System Generated Number

  • 0000144832

Structure Descriptors

InChI

1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14)

InChIKey

GECHUMIMRBOMGK-UHFFFAOYSA-N

Smiles

c1ccnc(c1)NS(=O)(=O)c2ccc(cc2)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Pharmacology and Experimental Therapeutics. Vol. 67, Pg. 454, 1939.
mouse LD50 intraperitoneal 1150mg/kg (1150mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archivum Immunologiae et Therapiae Experimentalis. Vol. 16, Pg. 804, 1968.
mouse LD50 oral 16600mg/kg (16600mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: TREMOR
Quarterly Journal of Pharmacy & Pharmacology. Vol. 11, Pg. 217, 1938.
rabbit LDLo oral 20gm/kg (20000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Archives Internationales de Pharmacodynamie et de Therapie. Vol. 62, Pg. 281, 1939.
rat LD50 intravenous 800mg/kg (800mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 367, 1950.
rat LD50 oral 15800mg/kg (15800mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE WEAKNESS

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Quarterly Journal of Pharmacy & Pharmacology. Vol. 11, Pg. 217, 1938.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 192 deg C   EXP
pKa Dissociation Constant 8.43 (none)   EXP
log P (octanol-water) 0.35 (none)   EXP
Water Solubility 268 mg/L 25 EXP
Vapor Pressure 6.27E-08 mm Hg 25 EST
Henry's Law Constant 1.08E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.11E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.