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Substance Name: Clioxanide [USAN:INN:BAN]
RN: 14437-41-3
UNII: 2Q9A409N0B
InChIKey: ICKMASVVMCGZLR-UHFFFAOYSA-N

Classification Codes

  • Anthelmintic
  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H10-Cl-I2-N-O3

Molecular Weight

  • 541.501
 
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Names and Synonyms

Name of Substance

  • Clioxanide
  • Clioxanide [USAN:INN:BAN]

Synonyms

  • 2-(4-Chlorphenylcarbamoyl)-4,6-diodphenyl acetat
  • 2-(Acetyloxy)-N-(4-chlorophenyl)-3,5-diiodobenzamide
  • 2-Acetoxy-3,5-diiodo-4'-chlorobenzanilide
  • 2-Acetoxy-4'-chloro-3,5-di-iodobenzanilide
  • 4'-Chloro-3,5-diiodosalicylanilide acetate
  • Acetoxy-4'-chloro-3,5-diiodobenzanilide
  • Benzamide, 2-(acetyloxy)-N-(4-chlorophenyl)-3,5-diiodo-
  • Benzanilide, 4'-chloro-3,5-diiodo-2-hydroxy-, acetate
  • BRN 2950514
  • CI-633
  • CL 633
  • Clioxanida
  • Clioxanida [INN-Spanish]
  • Clioxanide
  • Clioxanidum
  • Clioxanidum [INN-Latin]
  • CN 59,567
  • CN 59567
  • EINECS 238-414-0
  • NSC 233846
  • Salicylanilide, 4'-chloro-3,5-diiodo-, acetate ester
  • SYD 230
  • SYD-230
  • Tremerad
  • UNII-2Q9A409N0B

Systematic Names

  • 4'-Chloro-3,5-diiodosalicylanilide acetate
  • Benzamide, 2-(acetyloxy)-N-(4-chlorophenyl)-3,5-diiodo-
  • Clioxanide
  • Salicylanilide, 4'-chloro-3,5-diiodo-, acetate ester

Registry Numbers

CAS Registry Number

  • 14437-41-3

FDA UNII

  • 2Q9A409N0B

System Generated Number

  • 0014437413

Structure Descriptors

InChI

1S/C15H10ClI2NO3/c1-8(20)22-14-12(6-10(17)7-13(14)18)15(21)19-11-4-2-9(16)3-5-11/h2-7H,1H3,(H,19,21)

InChIKey

ICKMASVVMCGZLR-UHFFFAOYSA-N

Smiles

c1(c(c(cc(c1)I)I)OC(C)=O)C(Nc1ccc(Cl)cc1)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
domestic animals - goat/sheep LD50 unreported 414mg/kg (414mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Australian Veterinary Journal. Vol. 46, Pg. 297, 1970.
mouse LD50 intraperitoneal 720mg/kg (720mg/kg)   Australian Veterinary Journal. Vol. 46, Pg. 297, 1970.
mouse LD50 intraperitoneal 720mg/kg (720mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Australian Veterinary Journal. Vol. 46, Pg. 297, 1970.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Australian Veterinary Journal. Vol. 46, Pg. 297, 1970.
rat LD50 oral > 5gm/kg (5000mg/kg)   Australian Veterinary Journal. Vol. 46, Pg. 297, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 215.5 deg C   EXP
log P (octanol-water) 5.280 (none)   EST
Atmospheric OH Rate Constant 3.93E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.