Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Paliperidone [USAN:INN:BAN:JAN]
RN: 144598-75-4
UNII: 838F01T721
InChIKey: PMXMIIMHBWHSKN-UHFFFAOYSA-N

Note

  • Long-acting, once daily.

Molecular Formula

  • C23-H27-F-N4-O3

Molecular Weight

  • 426.4893
 

Classification Codes

  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Psychotropic Drugs
  • Tranquilizing Agents
  • Treatment of Schizophrenia

Names and Synonyms

Name of Substance

  • 9-Hydroxy-risperidone
  • Paliperidone
  • Paliperidone [USAN:INN:BAN:JAN]

Synonyms

  • (9RS)-3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl))ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimidin-4-one
  • 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-
  • 9-Hydroxy-risperidone
  • 9-Hydroxyrisperidone
  • 9-OH-risperidone
  • HSDB 5716
  • HSDB 8148
  • Invega
  • Paliperidone
  • R 76477
  • R-76477
  • RO76477
  • UNII-838F01T721

Systematic Names

  • 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8-tetrahydro-9-hydroxy-2-methyl-
  • 4H-Pyrido(2,1-a)pyrimidin-4-one, 6,7,8,9-tetrahydro-3-(2-(4-(6-fluro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-9-hydroxy-2-methyl-

Registry Numbers

CAS Registry Number

  • 144598-75-4

FDA UNII

  • 838F01T721

Other Registry Numbers

  • 130049-84-2
  • 130049-86-4
  • 147687-18-1

System Generated Number

  • 0144598754

Structure Descriptors

InChI

1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3

InChIKey

PMXMIIMHBWHSKN-UHFFFAOYSA-N

Smiles

Cc1c(c(=O)n2c(n1)C(CCC2)O)CCN3CCC(CC3)c4c5ccc(cc5on4)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral 65mg/kg (65mg/kg)   Drug Development Research. Vol. 33, Pg. 399, 1994.