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Substance Name: Beigene-283
RN: 1446090-79-4
UNII: 8762XZS5ZF
InChIKey: NGFFVZQXSRKHBM-FKBYEOEOSA-N

Note

  • A BRAF inhibitor.

Molecular Formula

  • C25-H17-F3-N4-O3

Molecular Weight

  • 478.4283
 
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Names and Synonyms

Name of Substance

  • Beigene-283

Synonyms

  • 1,8-Naphthyridin-2(1H)-one, 5-(((1R,1aS,6bR)-1a,6b-dihydro-1-(6-(trifluoromethyl)-1H-benzimidazol-2-yl)-1H-cyclopropa(b)benzofuran-5-yl)oxy)-3,4-dihydro-
  • 5-(((1R,1aS,6bR)-1-(6-(Trifluoromethyl)-1H-benzimidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa(b)benzofuran-5-yl)oxy)-3,4-dihydro-1H-1,8-naphthyridin-2-one
  • Beigene-283
  • BGB-283
  • UNII-8762XZS5ZF

Registry Numbers

CAS Registry Number

  • 1446090-79-4

FDA UNII

  • 8762XZS5ZF

System Generated Number

  • 1446090794

Structure Descriptors

InChI

1S/C25H17F3N4O3/c26-25(27,28)11-1-4-15-16(9-11)31-24(30-15)21-20-14-10-12(2-5-17(14)35-22(20)21)34-18-7-8-29-23-13(18)3-6-19(33)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,31)(H,29,32,33)/t20-,21-,22-/m0/s1

InChIKey

NGFFVZQXSRKHBM-FKBYEOEOSA-N

Smiles

FC(F)(F)c1ccc2nc([nH]c2c1)[C@@H]3[C@H]4Oc5ccc(Oc6ccnc7NC(=O)CCc67)cc5[C@@H]34