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Substance Name: Neuropilin-1
RN: 144713-63-3


  • A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.
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Names and Synonyms

Name of Substance

  • Neuropilin-1

MeSH Heading

  • Neuropilin-1


  • A5 antigen
  • Neuropilin
  • Neuroporin-2
  • Npn-1 protein
  • Npn-2 protein
  • Sema III receptor
  • Semaphorin III receptor

Systematic Name

  • Antigen A 5 (Xenopus laevis clone 112/18/42b reduced)

Registry Numbers

CAS Registry Number

  • 144713-63-3

System Generated Number

  • 0144713633