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Substance Name: Ivosidenib [USAN:INN]
RN: 1448347-49-6
UNII: Q2PCN8MAM6
InChIKey: WIJZXSAJMHAVGX-DHLKQENFSA-N

Note

  • An inhibitor of isocitrate dehydrogenase 1 (IDH1) for treatment of acute myeloid leukemia (AML).

Molecular Formula

  • C28-H22-Cl-F3-N6-O3

Molecular Weight

  • 582.9678
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Treatment of Cancer
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Names and Synonyms

Results Name

  • Ivosidenib [USAN:INN]

Name of Substance

  • Ivosidenib
  • Ivosidenib [USAN]

Synonyms

  • AG-120
  • Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-
  • Ivosidenib
  • Ivosidenib [INN]
  • Ivosidenib [WHO-DD]
  • UNII-Q2PCN8MAM6

Registry Numbers

CAS Registry Number

  • 1448347-49-6

FDA UNII

  • Q2PCN8MAM6

System Generated Number

  • 1448347496

Structure Descriptors

InChI

InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1

InChIKey

WIJZXSAJMHAVGX-DHLKQENFSA-N

Smiles

Fc1cncc(c1)N([C@H](C(=O)NC2CC(F)(F)C2)c3ccccc3Cl)C(=O)[C@@H]4CCC(=O)N4c5cc(ccn5)C#N