Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Deflazacort [USAN:INN:BAN]
RN: 14484-47-0
UNII: KR5YZ6AE4B
InChIKey: FBHSPRKOSMHSIF-GRMWVWQJSA-N

Note

  • DrugBank: Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. It was approved in February, 2017 by the FDA for use in treatment of Duchenne muscular dystrophy (trade name Emflaza).

Molecular Formula

  • C25-H31-N-O6

Molecular Weight

  • 441.5209
 

Classification Codes

  • Anti-Inflammatory
  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Hormone
  • Immunologic Factors
  • Immunosuppressive Agents
  • Tumor Data
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Deflazacort [USAN:INN:BAN]
  • Oxazacort

Synonyms

  • 11beta,21-Dihydroxy-2'-methyl-5'betaH-pregna-1,4-dieno(17,16-d)oxazole-3,20-dione 21-acetate
  • 5'H-Pregna-1,4-dieno(17,16-d)oxazole-3,20-dione, 21-(acetyloxy)-11-hydroxy-2'-methyl-, (11beta,16beta)-
  • Azacort
  • Calcort
  • Deflan
  • Deflazacort
  • Deflazacortum
  • Deflazacortum [INN-Latin]
  • DL-458-IT
  • EINECS 238-483-7
  • Emflaza
  • Enzocort
  • Flantadin
  • L-5458
  • Lantadin
  • MDL 458
  • Oxazacort
  • UNII-KR5YZ6AE4B

Systematic Names

  • (11beta,16beta)-21-(Acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno(17,16-d)oxazole-3,20-dione
  • 5'-beta-H-Pregna-1,4-dieno(17,16-d)oxazole-3,20-dione, 11-beta,21-dihydroxy-2'-methyl-, 21-acetate
  • 5'H-Pregna-1,4-dieno(17,16-d)oxazole-3,20-dione, 21-(acetyloxy)-11-hydroxy-2'-methyl-, (11beta,16beta)-
  • Deflazacort

Registry Numbers

CAS Registry Number

  • 14484-47-0

FDA UNII

  • KR5YZ6AE4B

Other Registry Number

  • 74712-90-6

System Generated Number

  • 0014484470

Structure Descriptors

InChI

1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3/t17-,18-,19-,21+,22+,23-,24-,25+/m0/s1

InChIKey

FBHSPRKOSMHSIF-GRMWVWQJSA-N

Smiles

[C@@]12([C@@]3([C@@H](C[C@H]1OC(=N2)C)[C@H]1[C@H]([C@H](C3)O)[C@@]2(C(=CC(=O)C=C2)CC1)C)C)C(=O)COC(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo unreported 45mg/kg/2.5Y- (45mg/kg) SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Clinical Nephrology. Vol. 47, Pg. 205, 1997.
mouse LD50 oral 5200mg/kg (5200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1543, 1980.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 256 deg C   EXP
log P (octanol-water) 1.310 (none)   EST
Atmospheric OH Rate Constant 9.17E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.