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Substance Name: Dehydrocholate sodium [USP]
RN: 145-41-5
UNII: W4193719XR
InChIKey: FKJIJBSJQSMPTI-CAOXKPNISA-M

Note

  • A semisynthetic bile acid made from cholic acid. It is used as a cholagogue, hydrocholeretic, diuretic, and as a diagnostic aid.

Molecular Formula

  • C24-H34-O5.Na

Molecular Weight

  • 424.5097
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Dehydrocholate sodium [USP]
  • Sodium dehydrocholate [INN]

Synonyms

  • 5-beta-Cholan-24-oic acid, 3,7,12-trioxo-, monosodium salt
  • Biliron
  • Biliton
  • Carachol
  • Cholan-24-oic acid, 3,7,12-trioxo-, sodium salt, (5-beta)-
  • Decholin Sodium
  • Decholin sodium salt
  • Dehidrocolato sodico
  • Dehidrocolato sodico [INN-Spanish]
  • Dehydrocholate de sodium
  • Dehydrocholate de sodium [INN-French]
  • Dehydrocholate sodium
  • Dehydrocholic acid sodium salt
  • Dehydrocholic acid, sodium salt
  • Dilabil sodium
  • Dycholium
  • EINECS 205-652-1
  • Natrii dehydrocholas
  • Natrii dehydrocholas [INN-Latin]
  • Natriumdehydrocholat
  • Natriumdehydrocholat [German]
  • Sodium 3,7,12-triketocholanate
  • Sodium 3,7,12-trioxo-5-beta-cholan-24-oate
  • Sodium 3,7,12-trioxo-5-beta-cholanate
  • Sodium 3,7,12-trioxo-5beta-cholan-24-oate
  • Sodium dehydrocholate
  • Suprachol
  • Triceto 3-7-12 cholanate de Na
  • Triceto 3-7-12 cholanate de Na [French]
  • UNII-W4193719XR

Systematic Names

  • 5-beta-Cholan-24-oic acid, 3,7,12-trioxo-, sodium salt
  • Cholan-24-oic acid, 3,7,12-trioxo-, sodium salt, (5beta)-
  • Sodium dehydrocholate

Registry Numbers

CAS Registry Number

  • 145-41-5

FDA UNII

  • W4193719XR

Other Registry Number

  • 1510-17-4

Related Registry Number

  • 81-23-2 (Parent)

System Generated Number

  • 0000145415

Molecular Formulas

Molecular Formula

  • C24-H34-O5.Na

Molecular Formula Fragments

  • C24-H34-O5
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C24H34O5.Na/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;/h13-14,16-18,22H,4-12H2,1-3H3,(H,28,29);/q;+1/p-1/t13-,14+,16-,17+,18+,22+,23+,24-;/m1./s1

InChIKey

FKJIJBSJQSMPTI-CAOXKPNISA-M

Smiles

[C@H]12[C@H]3[C@@]([C@H](CC3)[C@@H](CCC(=O)[O-])C)(C(=O)C[C@@H]1[C@@]1([C@H](CC2=O)CC(=O)CC1)C)C.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1480mg/kg (1480mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 280, 1970.
mouse LD50 intravenous 1100mg/kg (1100mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yonago Igaku Zasshi. Journal of the Yonago Medical Association. Vol. 25, Pg. 70, 1974.
mouse LD50 oral 2150mg/kg (2150mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Yonago Igaku Zasshi. Journal of the Yonago Medical Association. Vol. 25, Pg. 70, 1974.
mouse LD50 subcutaneous 1350mg/kg (1350mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yonago Igaku Zasshi. Journal of the Yonago Medical Association. Vol. 25, Pg. 70, 1974.
rabbit LDLo intravenous 1gm/kg (1000mg/kg) GASTROINTESTINAL: OTHER CHANGES

BLOOD: OTHER CHANGES

CARDIAC: OTHER CHANGES
Zeitschrift fuer die Gesamte Experimentelle Medizin. Vol. 52, Pg. 779, 1926.
rat LD50 intraperitoneal 1100mg/kg (1100mg/kg)   Chimica Therapeutica. Vol. 5, Pg. 188, 1970.
rat LD50 intravenous 887mg/kg (887mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 280, 1970.
rat LD50 oral 3755mg/kg (3755mg/kg)   German Offenlegungsschrift Patent Document. Vol. #2630169,
rat LD50 subcutaneous 2300mg/kg (2300mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Yonago Igaku Zasshi. Journal of the Yonago Medical Association. Vol. 25, Pg. 70, 1974.