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Substance Name: Bupranolol [INN:DCF]
RN: 14556-46-8
UNII: 858YGI5PIT
InChIKey: HQIRNZOQPUAHHV-UHFFFAOYSA-N
Note
- An adrenergic-beta-2 antagonist that has been used for cardiac arrhythmia, angina pectoris, hypertension, glaucoma, and as an antithrombotic.
Molecular Formula
- C14-H22-Cl-N-O2
Molecular Weight
- 271.7858
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenergic Agents
- Adrenergic Antagonists
- Adrenergic beta-Antagonists
- Anti-Arrhythmia Agents
- Antihypertensive Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Neurotransmitter Agents
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Links to Resources
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Names and Synonyms
Name of Substance
- Bupranolol [INN:DCF]
- SK&F 16805-A
MeSH Heading
- Bupranolol
Synonyms
- 1-(tert-Butylamino)-3-((6-chloro-m-tolyl)-oxy)-2-propanol
- 2-Propanol, 1-(2-chloro-5-methylphenoxy)-3-((1,1-dimethylethyl)amino)-
- 2-Propanol, 1-(tert-butylamino)-3-(6-chloro-m-tolyloxy)-
- 3-(tert-Butylamino)-1-(6-chloro-m-tolyloxy)-2-propanol
- B 1312
- B 1312 [as hydrochloride]
- BRN 2272923
- Bupranolol
- Bupranololum
- Bupranololum [INN-Latin]
- KL 255
- KL-255 [as hydrochloride]
- Ophtorenin
- UNII-858YGI5PIT
Systematic Names
- 1-(tert-Butylamino)-3-((6-chloro-m-tolyl)-oxy)-2-propanol
- 1-t-Butylamino-3-(2-chloro-5-methylphenoxy) -2-propanol
- 2-Propanol, 1-(tert-butylamino)-3-((6-chloro-m-tolyl)oxy)- (8CI)
- 2-Propanol, 1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)-
Registry Numbers
CAS Registry Number
- 14556-46-8
FDA UNII
- 858YGI5PIT
Other Registry Number
- 70578-42-6
System Generated Number
- 0014556468
Structure Descriptors
InChI
1S/C14H22ClNO2/c1-10-5-6-12(15)13(7-10)18-9-11(17)8-16-14(2,3)4/h5-7,11,16-17H,8-9H2,1-4H3InChIKey
HQIRNZOQPUAHHV-UHFFFAOYSA-NSmiles
Cc1ccc(c(c1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 45mg/kg (45mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1022, 1977. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 220-222 | deg C | EXP | |
log P (octanol-water) | 2.97 | (none) | EXP | |
Water Solubility | 739 | mg/L | 25 | EST |
Vapor Pressure | 5.71E-07 | mm Hg | 25 | EST |
Henry's Law Constant | 8.88E-12 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.08E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.