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Substance Name: Sporidesmin A
RN: 1456-55-9
UNII: H70LC3H0RW
InChIKey: QTONANGUNATZOU-ICTVWZTPSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Natural Product

Molecular Formula

  • C18-H20-Cl-N3-O6-S2

Molecular Weight

  • 473.956
 
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Names and Synonyms

Name of Substance

  • Sporidesmin
  • Sporidesmin A

Synonyms

  • CCRIS 5323
  • Hydroxysporidesmin B
  • NSC 246152
  • Sporidesmin
  • Sporidesmin A
  • SPORIDESMIN BENZENE SOLVATE
  • UNII-H70LC3H0RW

Systematic Names

  • 3,11a-Epidithio-11aH-pyrazino(1',2':1,5)pyrrolo(2,3-b)indole-1,4-dione, 9-chloro-2,3,5a,6,10b,11-hexahydro-10b,11-dihydroxy-7,8-dimethoxy-2,3,6-trimethyl-, (3-alpha,5a-alpha,10b-alpha,11-beta,11a-alpha)-
  • Sporidesmin

Registry Numbers

CAS Registry Number

  • 1456-55-9

FDA UNII

  • H70LC3H0RW

Other Registry Numbers

  • 1378-20-7
  • 54868-51-8

System Generated Number

  • 0001456559

Structure Descriptors

InChI

1S/C18H20ClN3O6S2/c1-16-14(24)22-13-17(26,12(23)18(22,30-29-16)15(25)21(16)3)7-6-8(19)10(27-4)11(28-5)9(7)20(13)2/h6,12-13,23,26H,1-5H3/t12-,13-,16-,17-,18-/m1/s1

InChIKey

QTONANGUNATZOU-ICTVWZTPSA-N

Smiles

N12[C@]3(C(N([C@@](C2=O)(C)SS3)C)=O)[C@@H]([C@@]2(O)c3cc(Cl)c(c(c3N(C)[C@H]12)OC)OC)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
domestic animals - goat/sheep LDLo oral 1mg/kg (1mg/kg)   Research in Veterinary Science. Vol. 11, Pg. 183, 1970.
mouse LD50 intravenous 1mg/kg (1mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 175, 1980.
mouse LD50 oral 23600ug/kg (23.6mg/kg) LIVER: OTHER CHANGES

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Journal of Animal Science. Vol. 78, Pg. 2157, 2000.