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Substance Name: Triflupromazine [USP:INN:BAN]
RN: 146-54-3
UNII: RO16TQF95Y
InChIKey: XSCGXQMFQXDFCW-UHFFFAOYSA-N

Note

  • A phenothiazine used as an antipsychotic agent and as an antiemetic.

Molecular Formula

  • C18-H19-F3-N2-S

Molecular Weight

  • 352.4221
 

Classification Codes

  • Antiemetics
  • Antipsychotic
  • Antipsychotic Agents
  • Autonomic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dopamine Agents
  • Dopamine Antagonists
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Mutation Data
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents

Names and Synonyms

Name of Substance

  • Triflupromazine
  • Triflupromazine [USP:INN:BAN]

MeSH Heading

  • Triflupromazine

Synonyms

  • 10-(3-(Dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine
  • 10-3-(Dimethylamino)propyl-2-(trifluoromethyl)phenothiazine
  • 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-
  • 2-(Trifluoromethyl)promazine
  • 2-Trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine
  • Adazine
  • EINECS 205-673-6
  • Fluopromazine
  • HSDB 3407
  • N,N-Dimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine
  • Phenothiazine, 10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)-
  • Psyquil
  • Siquil
  • Trifluopromazine
  • Triflupromazina
  • Triflupromazina [INN-Spanish]
  • Triflupromazine
  • Triflupromazinum
  • Triflupromazinum [INN-Latin]
  • UNII-RO16TQF95Y
  • Vesprin
  • Vetame

Systematic Names

  • 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-
  • Phenothiazine, 10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)-
  • Triflupromazine

Registry Numbers

CAS Registry Number

  • 146-54-3

FDA UNII

  • RO16TQF95Y

System Generated Number

  • 0000146543

Structure Descriptors

InChI

1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3

InChIKey

XSCGXQMFQXDFCW-UHFFFAOYSA-N

Smiles

CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 100mg/kg (100mg/kg)   Mutation Research. Vol. 17, Pg. 87, 1973.
mouse LD50 intravenous 34mg/kg (34mg/kg)   Japanese Journal of Toxicology. Vol. 4, Pg. 121, 1991.
mouse LD50 oral 245mg/kg (245mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 540, 1960.
rat LD50 intraperitoneal 94mg/kg (94mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 540, 1960.
rat LD50 oral 185mg/kg (185mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 797, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 5.54 (none)   EXP
Water Solubility 0.175 mg/L 25 EST
Vapor Pressure 5.42E-07 mm Hg 25 EST
Henry's Law Constant 4.32E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.29E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.