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Substance Name: Fluphenazine hydrochloride [USP:BAN:JAN]
RN: 146-56-5
UNII: ZOU145W1XL
InChIKey: MBHNWCYEGXQEIT-UHFFFAOYSA-N

Note

  • A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.

Molecular Formula

  • C22-H26-F3-N3-O-S.2Cl-H

Molecular Weight

  • 510.4492
 

Classification Codes

  • Antipsychotic
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Fluphenazine hydrochloride [USP:BAN:JAN]

Synonyms

  • 1-(2-Hydroxyethyl)-4-(3-(2-trifluoromethyl-10-phenothiazinylpropyl)piperazine dihydrochloride
  • 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-, dihydrochloride
  • 10-(3-(4-(2-Hydroxyethyl)piperazinyl)propyl)-2-trifluoromethylphenothiazine dihydrochloride
  • 4-(3-(2-(Trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazineethanol dihydrochloride
  • A 4077
  • Anatensol
  • Calmansial
  • CCRIS 4032
  • EINECS 205-674-1
  • Flufenazin
  • Fluorophenazine dihydrochloride
  • Fluphenazine chloride
  • Fluphenazine dihydrochloride
  • Fluphenazine HCl
  • Fluphenazine hydrochloride
  • Liogen
  • Lyorodin
  • Mirenil
  • Moditen
  • NSC 179197
  • OMCA
  • Permitil
  • Permitil hydrochloride
  • Prolixin
  • Squibb 4918
  • Tensofin
  • Trancin
  • UNII-ZOU145W1XL

Systematic Names

  • 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-, dihydrochloride
  • 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-, dihydrochloride
  • Fluphenazine dihydrochloride

Registry Numbers

CAS Registry Number

  • 146-56-5

FDA UNII

  • ZOU145W1XL

Other Registry Number

  • 36315-90-9

System Generated Number

  • 0000146565

Molecular Formulas

Molecular Formula

  • C22-H26-F3-N3-O-S.2Cl-H

Molecular Formula Fragments

  • C22-H26-F3-N3-O-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H

InChIKey

MBHNWCYEGXQEIT-UHFFFAOYSA-N

Smiles

c1ccc2c(c1)N(c3cc(ccc3S2)C(F)(F)F)CCCN4CCN(CC4)CCO.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 299mg/kg (299mg/kg)   Pharmazie. Vol. 38, Pg. 749, 1983.
human TDLo oral 2800ug/kg/2W- (2.8mg/kg) MUSCULOSKELETAL: OTHER CHANGES British Medical Journal. Vol. 2, Pg. 1071, 1966.
mouse LD50 intraperitoneal 89mg/kg (89mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 24, 1972.
mouse LD50 intravenous 56mg/kg (56mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00179,
mouse LD50 oral 220mg/kg (220mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 24, 1972.