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Substance Name: Selegiline hydrochloride [USAN:USP]
RN: 14611-52-0
UNII: 6W731X367Q
InChIKey: IYETZZCWLLUHIJ-UTONKHPSSA-N

Note

  • A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.

Molecular Formula

  • C13-H17-N.Cl-H

Molecular Weight

  • 223.7452
 

Classification Codes

  • Antidyskinetic
  • Antiparkinsonian (in Combination with Levodopa/Carbidopa)
  • Monoamine Oxidase Inhibitors
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Selegiline hydrochloride
  • Selegiline hydrochloride [USAN:USP]

Synonyms

  • (-)-(R)-N,alpha-Dimethyl-N-2-propynylphenethylamine hydrochloride
  • (-)-(R)-N,alpha-Dimethyl-N-2-propynylphenethylamine monohydrochloride
  • (-)-Deprenil hydrochloride
  • (-)-Deprenyl hydrochloride
  • (-)-E-250 hydrochloride
  • (-)-N,alpha-Dimethyl-N-2-propynylbenzeneethanamine hydrochloride
  • (-)-Phenylisopropylmethylpropynylamine
  • CCRIS 8571
  • Eldepryl
  • Eldepryl hydrochloride
  • Emsam
  • Ensam
  • FPF1100
  • HSDB 7183
  • Jumex hydrochloride
  • l-Deprenyl hydrochloride
  • Selegiline HCl
  • Selegiline hydrochloride
  • UNII-6W731X367Q
  • Zelapar

Systematic Name

  • Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, hydrochloride, (R)-

Registry Numbers

CAS Registry Number

  • 14611-52-0

FDA UNII

  • 6W731X367Q

Other Registry Number

  • 40602-63-9

Related Registry Number

  • 14611-51-9 (Parent)

System Generated Number

  • 0014611520

Molecular Formulas

Molecular Formula

  • C13-H17-N.Cl-H

Molecular Formula Fragments

  • C13-H17-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H/t12-;/m1./s1

InChIKey

IYETZZCWLLUHIJ-UTONKHPSSA-N

Smiles

Cl.C[C@H](Cc1ccccc1)N(C)CC#C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 unreported 121mg/kg (121mg/kg)   Acta Physiologica Academiae Scientiarum Hungaricae. Vol. 32, Pg. 377, 1967.
rat LD50 intravenous 81mg/kg (81mg/kg)   Acta Physiologica Academiae Scientiarum Hungaricae. Vol. 32, Pg. 377, 1967.
rat LD50 subcutaneous 280mg/kg (280mg/kg)   Acta Physiologica Academiae Scientiarum Hungaricae. Vol. 32, Pg. 377, 1967.