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Substance Name: Levomepate hydrochloride
RN: 14641-96-4
InChIKey: VAJSWYGXJIEKGX-QPOHYMPGSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C18-H25-N-O3.Cl-H

Molecular Weight

  • 339.86
 
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Names and Synonyms

Results Name

  • Levomepate hydrochloride

Synonyms

  • (-)-alpha-Methylhyoscyamine hydrochloride
  • (3(S)-endo)-8-Methyl-8-azabicyclo(3.2.1)oct-3-yl alpha-(hydroxymethyl)-alpha-methylbenzeneacetate
  • 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, (-)-2-methyl-2-phenylhydracrylate (ester), HCl
  • 3-alpha-Tropanyl (-)-2-methyl-2-phenylhydracrylate hydrochloride
  • 8-Methyl-8-azabicyclo(3.2.1)oct-3-yl alpha-(hydroxymethyl)-alpha-methylbenzeneacetate hydrochloride, (3(S)-endo)-
  • Levomepate HCl
  • Levomepate hydrochloride
  • Tropine (-)-alpha-methyltropate hydrochloride

Systematic Names

  • Benzeneacetic acid, alpha-(hydroxymethyl)-alpha-methyl-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrochloride, (3(S)-endo)-
  • Hydracrylic acid, (-)-2-methyl-2-phenyl-, 3-alpha-tropanyl ester, hydrochloride

Registry Numbers

CAS Registry Number

  • 14641-96-4

System Generated Number

  • 0014641964

Molecular Formulas

Molecular Formula

  • C18-H25-N-O3.Cl-H

Molecular Formula Fragments

  • C18-H25-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H25NO3.ClH/c1-18(12-20,13-6-4-3-5-7-13)17(21)22-16-10-14-8-9-15(11-16)19(14)2;/h3-7,14-16,20H,8-12H2,1-2H3;1H/t14?,15?,16?,18-;/m1./s1

InChIKey

VAJSWYGXJIEKGX-QPOHYMPGSA-N

Smiles

C1[C@@H](C[C@@H]2CC[C@@H]1N2C)OC([C@@](c1ccccc1)(CO)C)=O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 55mg/kg (55mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Toxicology and Applied Pharmacology. Vol. 10, Pg. 424, 1967.
mouse LD50 intraperitoneal 182mg/kg (182mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 296, 1970.
mouse LD50 intravenous 108mg/kg (108mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: IRRITABILITY

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Toxicology and Applied Pharmacology. Vol. 10, Pg. 424, 1967.
mouse LD50 oral 425mg/kg (425mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 296, 1970.
rabbit LD50 intraperitoneal 200mg/kg (200mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Toxicology and Applied Pharmacology. Vol. 10, Pg. 424, 1967.
rabbit LD50 intravenous 70mg/kg (70mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Toxicology and Applied Pharmacology. Vol. 10, Pg. 424, 1967.
rabbit LD50 subcutaneous 400mg/kg (400mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Toxicology and Applied Pharmacology. Vol. 10, Pg. 424, 1967.
rat LD50 intraperitoneal 226mg/kg (226mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 297, 1970.
rat LD50 oral 1100mg/kg (1100mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 297, 1970.