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Substance Name: Sarcolysine hydrochloride
RN: 1465-26-5
UNII: GEG3Q4FC64
InChIKey: OUUYBRCCFUEMLH-UHFFFAOYSA-N

Classification Code

  • Mutation Data

Molecular Formula

  • C13-H18-Cl2-N2-O2.Cl-H

Molecular Weight

  • 341.6641
 
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Names and Synonyms

Results Name

  • Sarcolysine hydrochloride

Name of Substance

  • Sarcolysin hydrochloride

Synonyms

  • 3-(p-(Bis(2-chloroethyl)amino)phenyl)-DL-alanine hydrochloride
  • 3-(p-(Bis(beta-chloroethyl)amino)phenyl)-D,L-alanine hydrochloride
  • 4-(Bis(2-chloroethyl)amino)-DL-phenylalanine hydrochloride
  • AI3-52155
  • Alkeran (Russian)
  • CB 3007
  • DL-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, hydrochloride
  • DL-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, monohydrochloride
  • DL-Phenylalanine mustard hydrochloride
  • DL-Sarcolysin monohydrochloride
  • DL-Sarcolysine hydrochloride
  • Melphalan (Russian)
  • NCS-14210
  • NSC 14210
  • Sarcolysin hydrochloride
  • Sarcolysine HCl
  • Sarcolysine hydrochloride
  • Sarkoklorin
  • Sarkolizin
  • SKI 21739
  • UNII-GEG3Q4FC64

Systematic Names

  • Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, hydrochloride, DL
  • Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, monohydrochloride, DL- (8CI)
  • DL-Phenylalanine, 4-(bis(2-chloroethyl)amino)-, monohydrochloride (9CI)

Registry Numbers

CAS Registry Number

  • 1465-26-5

FDA UNII

  • GEG3Q4FC64

Other Registry Number

  • 13469-52-8

System Generated Number

  • 0001465265

Molecular Formulas

Molecular Formula

  • C13-H18-Cl2-N2-O2.Cl-H

Molecular Formula Fragments

  • C13-H18-Cl2-N2-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C13H18Cl2N2O2.ClH/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;/h1-4,12H,5-9,16H2,(H,18,19);1H

InChIKey

OUUYBRCCFUEMLH-UHFFFAOYSA-N

Smiles

Cl.NC(Cc1ccc(cc1)N(CCCl)CCCl)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 430ug/kg (0.43mg/kg) BLOOD: OTHER CHANGES

BLOOD: THROMBOCYTOPENIA

BLOOD: LEUKOPENIA
Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 201, 1965.
monkey LDLo intravenous 860ug/kg (0.86mg/kg) BLOOD: OTHER CHANGES

BLOOD: LEUKOPENIA

GASTROINTESTINAL: OTHER CHANGES
Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 201, 1965.
mouse LD50 oral 44600ug/kg (44.6mg/kg) BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 11(3), Pg. 28, 1967.
mouse LDLo unreported 20mg/kg (20mg/kg)   Farmakologiya i Toksikologiya Vol. 37, Pg. 192, 1974.
rat LD50 intraperitoneal 16200ug/kg (16.2mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 11(3), Pg. 28, 1967.
rat LD50 oral 52mg/kg (52mg/kg) BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

ENDOCRINE: CHANGES IN SPLEEN WEIGHT
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 11(3), Pg. 28, 1967.
rat LDLo intratracheal 5mg/kg (5mg/kg) BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE

LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 11(3), Pg. 28, 1967.
rat LDLo unreported 15mg/kg (15mg/kg)   Farmakologiya i Toksikologiya Vol. 37, Pg. 192, 1974.