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Substance Name: Eptaplatin [USAN:INN]
RN: 146665-77-2
UNII: 1352HON1DH
InChIKey: XJXKGUZINMNEDK-GPJOBVNKSA-L

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C11-H20-N2-O6-Pt

Molecular Weight

  • 471.367
 
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Names and Synonyms

Name of Substance

  • Eptaplatin [USAN:INN]
  • SKI 2053R

Synonyms

  • cis-((4R,5R)-2-Isopropyl-1,3-dioxolane-4,5-bis(methylamine)-N,N')(malonato(2-)-O,O')platinum
  • cis-Malonato((4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane)platinum(II)
  • Eptaplatin
  • NSC D644591
  • SKI 2053R
  • UNII-1352HON1DH

Systematic Names

  • Platinum, ((4R,5R)-2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-kappaN4,kappaN5)(propanedioato(2-)-kappaO1,kappaO3)-, (SP-4-2)-
  • Platinum, (2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-N,N')(propanedioato(2-)-O,O')-, (SP-4-2-(4R-(2-alpha,4-alpha,5-beta)))-

Registry Numbers

CAS Registry Number

  • 146665-77-2

FDA UNII

  • 1352HON1DH

System Generated Number

  • 0146665772

Structure Descriptors

InChI

1S/C8H18N2O2.C3H4O4.Pt/c1-5(2)8-11-6(3-9)7(4-10)12-8;4-2(5)1-3(6)7;/h5-8H,3-4,9-10H2,1-2H3;1H2,(H,4,5)(H,6,7);/q;;+2/p-2/t6-,7-;;/m1../s1

InChIKey

XJXKGUZINMNEDK-GPJOBVNKSA-L

Smiles

[O-]C(CC([O-])=O)=O.NC[C@H]1OC(O[C@@H]1CN)C(C)C.[Pt+2]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 198mg/kg (198mg/kg)   Korean Journal of Toxicology. Vol. 8, Pg. 205, 1993.
mouse LD50 oral 1590mg/kg (1590mg/kg)   Korean Journal of Toxicology. Vol. 8, Pg. 205, 1993.
rat LD50 intraperitoneal 182mg/kg (182mg/kg)   Korean Journal of Toxicology. Vol. 8, Pg. 205, 1993.
rat LDLo oral 2gm/kg (2000mg/kg)   Korean Journal of Toxicology. Vol. 8, Pg. 205, 1993.