Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Todralazine [INN:BAN]
RN: 14679-73-3
UNII: WEN3K83YKD
InChIKey: WGZDBVOTUVNQFP-UHFFFAOYSA-N

Note

  • An antihypertensive agent with both central and peripheral action; it has some central nervous system depressant effects.

Molecular Formula

  • C11-H12-N4-O2

Molecular Weight

  • 232.2418
 

Classification Codes

  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Todralazine [INN:BAN]

MeSH Heading

  • Todralazine

Synonyms

  • 3-(1-Phthalazinyl)carbazic acid ethyl ester
  • 5-25-17-00414 (Beilstein Handbook Reference)
  • BRN 0233300
  • BT 621
  • BT 621 [as hydrochloride]
  • Carboethoxyphthalazinohydrazine
  • CEPH [as hydrochloride]
  • Ethyl 3-(1-phthalazinyl)carbazate
  • N-Carboethoxy-N'-phthalazino-hydrazine
  • Todralacina
  • Todralacina [Spanish]
  • Todralazina
  • Todralazina [INN-Spanish]
  • Todralazine
  • Todralazinum
  • Todralazinum [INN-Latin]
  • UNII-WEN3K83YKD

Systematic Names

  • Carbazic acid, 3-(1-phthalazinyl)-, ethyl ester
  • Ethyl 3-(1-phthalazinyl)carbazate
  • Hydrazinecarboxylic acid, 2-(1-phthalazinyl)-, ethyl ester (9CI)

Registry Numbers

CAS Registry Number

  • 14679-73-3

FDA UNII

  • WEN3K83YKD

System Generated Number

  • 0014679733

Structure Descriptors

InChI

1S/C11H12N4O2/c1-2-17-11(16)15-14-10-9-6-4-3-5-8(9)7-12-13-10/h3-7H,2H2,1H3,(H,13,14)(H,15,16)

InChIKey

WGZDBVOTUVNQFP-UHFFFAOYSA-N

Smiles

CCOC(=O)NNc1c2ccccc2cnn1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LD50 oral 650mg/kg (650mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 32, Pg. 104, 1968.
frog LD50 parenteral 636mg/kg (636mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 32, Pg. 104, 1968.
mouse LD50 intramuscular 417mg/kg (417mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 32, Pg. 104, 1968.
mouse LD50 intraperitoneal 382mg/kg (382mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 32, Pg. 104, 1968.
mouse LD50 intravenous 60mg/kg (60mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 32, Pg. 104, 1968.
rat LD50 intramuscular 333mg/kg (333mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 32, Pg. 104, 1968.
rat LD50 intraperitoneal 337mg/kg (337mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 32, Pg. 104, 1968.
rat LD50 intravenous 110mg/kg (110mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 32, Pg. 104, 1968.
rat LD50 oral 318mg/kg (318mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 31, Pg. 127, 1979.