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Substance Name: Alatrofloxacin [INN]
RN: 146961-76-4
UNII: 7QVV6I50DT
InChIKey: UUZPPAMZDFLUHD-VUJLHGSVSA-N

Note

  • Prodrug of trovafloxacin.

Molecular Formula

  • C26-H25-F3-N6-O5

Molecular Weight

  • 558.5145
 

Classification Codes

  • Anti-Infective Agents
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Topoisomerase II Inhibitors
  • Topoisomerase Inhibitors
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Names and Synonyms

Name of Substance

  • Alatrofloxacin [INN]

Synonyms

  • Alatrofloxacin
  • UNII-7QVV6I50DT

Systematic Names

  • L-Alaninamide, L-alanyl-N-((1alpha,5alpha,6alpha)-3-(6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl)-3-azabicyclo(310)hex-6-yl)-
  • L-Alaninamide, L-alanyl-N-(3-(6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl)-3-azabicyclo(310)hex-6-yl)-, (1alpha,5alpha,6alpha)-

Registry Numbers

CAS Registry Number

  • 146961-76-4

FDA UNII

  • 7QVV6I50DT

Other Registry Number

  • 157182-32-6

System Generated Number

  • 0146961764

Structure Descriptors

InChI

1S/C26H25F3N6O5/c1-10(30)24(37)31-11(2)25(38)32-20-14-7-34(8-15(14)20)23-18(29)6-13-21(36)16(26(39)40)9-35(22(13)33-23)19-4-3-12(27)5-17(19)28/h3-6,9-11,14-15,20H,7-8,30H2,1-2H3,(H,31,37)(H,32,38)(H,39,40)/t10-,11-,14-,15+,20+/m0/s1

InChIKey

UUZPPAMZDFLUHD-VUJLHGSVSA-N

Smiles

C[C@@H](C(=O)N[C@@H](C)C(=O)N[C@H]1[C@H]2[C@@H]1CN(C2)c3c(cc4c(=O)c(cn(c4n3)c5ccc(cc5F)F)C(=O)O)F)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TDLo intravenous 90mg/kg/4D-I (90mg/kg) BEHAVIORAL: HEADACHE

BLOOD: THROMBOCYTOPENIA

BLOOD: HEMORRHAGE
Annals of Pharmacotherpy. Vol. 34, Pg. 330, 2000.