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Substance Name: Tipepidine citrate
RN: 14698-07-8
UNII: IPZ5GQ4MX4
InChIKey: WQOYJMWVNIGIQR-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H17-N-S2.C6-H8-O7

Molecular Weight

  • 467.56
 
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Names and Synonyms

Name of Substance

  • Tipepidine citrate

Synonyms

  • 1-Methyl-3-(di-2-thienylmethylene)piperidine citrate
  • 3-(Di-2-thienylmethylene)-1-methylpiperidine citrate
  • Asverin citrate
  • Asverin-C
  • Asverine citrate
  • AT 327 citrate
  • Bithiodine
  • Piperidine, 3-(di-2-thienylmethylene)-1-methyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
  • UNII-IPZ5GQ4MX4

Systematic Name

  • Piperidine, 3-(di-2-thienylmethylene)-1-methyl-, citrate (1:1)

Registry Numbers

CAS Registry Number

  • 14698-07-8

FDA UNII

  • IPZ5GQ4MX4

Related Registry Number

  • 5169-78-8 (Parent)

System Generated Number

  • 0014698078

Molecular Formulas

Molecular Formula

  • C15-H17-N-S2.C6-H8-O7

Molecular Formula Fragments

  • C15-H17-N-S2
  • C6-H8-O7
  • COMPONENT

Structure Descriptors

InChI

1S/C15H17NS2.C6H8O7/c1-16-8-2-5-12(11-16)15(13-6-3-9-17-13)14-7-4-10-18-14;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-4,6-7,9-10H,2,5,8,11H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChIKey

WQOYJMWVNIGIQR-UHFFFAOYSA-N

Smiles

C1[N@@](CCC\C1=C(\c1cccs1)c1cccs1)C.C(C(CC(=O)O)(C(=O)O)O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 75mg/kg (75mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: FOOD INTAKE (ANIMAL)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Chemical and Pharmaceutical Bulletin. Vol. 7, Pg. 372, 1959.
mouse LD50 intraperitoneal 190mg/kg (190mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: TREMOR
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56(3), Pg. 69S, 1960.
mouse LD50 oral 867mg/kg (867mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3279, 1973.
mouse LD50 subcutaneous 376mg/kg (376mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: EXCITEMENT

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
Chemical and Pharmaceutical Bulletin. Vol. 7, Pg. 372, 1959.