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Substance Name: Trovafloxacin [INN]
RN: 147059-72-1
UNII: 9F388J00UK
InChIKey: WVPSKSLAZQPAKQ-CDMJZVDBSA-N

Note

  • A trifluoronaphthyridone derivative of 7-(3-azabicyclo(3.1.0)hexyl)naphthyridone; has antineoplastic activity.

Molecular Formula

  • C20-H15-F3-N4-O3

Molecular Weight

  • 416.3575
 

Classification Codes

  • Anti-Infective Agents
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Topoisomerase II Inhibitors
  • Topoisomerase Inhibitors

Names and Synonyms

Name of Substance

  • Trovafloxacin [INN]

Synonyms

  • Trovafloxacin
  • Trovan
  • UNII-9F388J00UK

Registry Numbers

CAS Registry Number

  • 147059-72-1

FDA UNII

  • 9F388J00UK

System Generated Number

  • 0147059721

Structure Descriptors

InChI

1S/C20H15F3N4O3/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24/h1-4,7,10-11,16H,5-6,24H2,(H,29,30)/t10-,11+,16+

InChIKey

WVPSKSLAZQPAKQ-CDMJZVDBSA-N

Smiles

c1cc(c(cc1F)F)n2cc(c(=O)c3c2nc(c(c3)F)N4C[C@@H]5[C@H](C4)[C@H]5N)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 7mg/kg/2D-I (7mg/kg) BLOOD: CHANGE IN CLOTTING FACTORS Annals of Internal Medicine. Vol. 131, Pg. 72, 1999.
man TDLo oral 40mg/kg/4W-I (40mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"

LIVER: OTHER CHANGES
New England Journal of Medicine. Vol. 342, Pg. 359, 2000.
women TDLo intravenous 12mg/kg/3D-I (12mg/kg) BLOOD: CHANGE IN CLOTTING FACTORS Annals of Internal Medicine. Vol. 131, Pg. 72, 1999.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 0.31 (none)   EXP
Water Solubility 12.3 mg/L 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.