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Substance Name: Rosuvastatin calcium [USAN]
RN: 147098-20-2
UNII: 83MVU38M7Q
InChIKey: LALFOYNTGMUKGG-BGRFNVSISA-L

Note

  • A HYDROXYMETHYLGLUTARYL-COA-REDUCTASE INHIBITOR, or statin, that reduces the plasma concentrations of LDL-CHOLESTEROL; APOLIPOPROTEIN B, and TRIGLYCERIDES while increasing HDL-CHOLESTEROL levels in patients with HYPERCHOLESTEROLEMIA and those at risk for CARDIOVASCULAR DISEASES.

Molecular Formula

  • C22-H28-F-N3-O6-S.1/2Ca

Molecular Weight

  • 1001.1466
 

Classification Codes

  • Anticholesteremic Agents
  • Antihyperlipidemic (HMGCoA Reductase Inhibitor)
  • Antimetabolites
  • Enzyme Inhibitors
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Hypolipidemic Agents
  • Lipid Regulating Agents

Names and Synonyms

Name of Substance

  • Rosuvastatin calcium [USAN]

MeSH Heading

  • Rosuvastatin Calcium

Synonyms

  • (S-(R*,S*-(E)))-7-(4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid, calcium salt (2:1)
  • 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)-
  • Crestor
  • Rosuvastatin calcium
  • Rosuvastatin hemicalcium
  • Rovista
  • S 4522
  • S-4522
  • UNII-83MVU38M7Q
  • ZD 4522
  • ZD 4522, calcium salt
  • ZD4522
  • ZD4522 (calcium salt)

Systematic Names

  • (S-((R*,S*-(E)))- 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl) amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid, calcium salt (2:1)
  • 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)

Registry Numbers

CAS Registry Number

  • 147098-20-2

FDA UNII

  • 83MVU38M7Q

System Generated Number

  • 0147098202

Molecular Formulas

Molecular Formula

  • C22-H28-F-N3-O6-S.1/2Ca

Molecular Formula Fragments

  • C22-H28-F-N3-O6-S
  • Ca
  • COMPONENT

Structure Descriptors

InChI

1S/2C22H28FN3O6S.Ca/c2*1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h2*5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30);/q;;+2/p-2/b2*10-9+;/t2*16-,17-;/m11./s1

InChIKey

LALFOYNTGMUKGG-BGRFNVSISA-L

Smiles

[Ca+2].CC(C)c1nc(nc(c1\C=C\[C@@H](O)C[C@@H](O)CC(=O)[O-])c2ccc(F)cc2)N(C)S(=O)(=O)C.CC(C)c3nc(nc(c3\C=C\[C@@H](O)C[C@@H](O)CC(=O)[O-])c4ccc(F)cc4)N(C)S(=O)(=O)C