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Substance Name: Pitavastatin calcium
RN: 147526-32-7
UNII: IYD54XEG3W
InChIKey: RHGYHLPFVJEAOC-FFNUKLMVSA-L

Note

  • DailyMed: LIVALO (pitavastatin) is an inhibitor of HMG-CoA reductase. It is a synthetic lipid-lowering agent for oral administration.

Molecular Formula

  • C25-H24-F-N-O4.1/2Ca

Molecular Weight

  • 880.9934
 

Classification Codes

  • Anticholesteremic Agents
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Hypolipidemic Agents

Names and Synonyms

Results Name

  • Pitavastatin calcium

Name of Substance

  • NK 104

Synonyms

  • Bis((3R,5S,6E)-7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoate), monocalcium salt
  • CCRIS 8652
  • Flovas
  • Livalo
  • NK 104 (acid)
  • NK-104
  • Pitavastatin calcium
  • Pitavastatin hemicalcium
  • UNII-IYD54XEG3W

Systematic Name

  • 6-Heptenoic acid, 7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydroxy-, calcium salt (2:1), (S-(R*,S*-(E)))-

Registry Numbers

CAS Registry Number

  • 147526-32-7

FDA UNII

  • IYD54XEG3W

Other Registry Number

  • 1187847-92-2

System Generated Number

  • 0147526327

Molecular Formulas

Molecular Formula

  • C25-H24-F-N-O4.1/2Ca

Molecular Formula Fragments

  • C25-H24-F-N-O4
  • Ca
  • COMPONENT

Structure Descriptors

InChI

1S/2C25H24FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;;+2/p-2/b2*12-11+;/t2*18-,19-;/m11./s1

InChIKey

RHGYHLPFVJEAOC-FFNUKLMVSA-L

Smiles

c1cc2c(c(c(nc2cc1)C3CC3)/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])c4ccc(cc4)F.c1cc2c(c(c(nc2cc1)C3CC3)/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])c4ccc(cc4)F.[Ca+2]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 100mg/kg (100mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA

GASTROINTESTINAL: NAUSEA OR VOMITING
Oyo Yakuri. Pharmacometrics. Vol. 56, Pg. 67, 1998.
rat LDLo oral 500mg/kg (500mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Oyo Yakuri. Pharmacometrics. Vol. 56, Pg. 67, 1998.