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Substance Name: Cyclin-Dependent Kinase Inhibitor p27
RN: 147604-94-2


  • A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.

Classification Codes

  • Enzyme Inhibitors
  • Protein Kinase Inhibitors
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Links to Resources

Names and Synonyms

Name of Substance

  • Cyclin-dependent kinase inhibitor P27

MeSH Heading

  • Cyclin-dependent kinase inhibitor P27


  • Cdkn1B gene product
  • Cdkn4 gene product
  • Cdkn4 protein
  • Kip1 gene product
  • p27 Kip1
  • p27(Kip)
  • p27(Kip1)
  • p27Kip1

Systematic Name

  • Protein (Saccharomyces cerevisiae clone pMR1703 gene KIP1 reduced)

Registry Numbers

CAS Registry Number

  • 147604-94-2

System Generated Number

  • 0147604942