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Substance Name: Benzarone [INN:DCF]
RN: 1477-19-6
UNII: 23ZW4BG89C
InChIKey: RFRXIWQYSOIBDI-UHFFFAOYSA-N

Note

  • Antihemorrhagic agent.

Molecular Formula

  • C17-H14-O3

Molecular Weight

  • 266.2946
 

Classification Codes

  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Fibrin Modulating Agents
  • Fibrinolytic Agents
  • Hematologic Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Benzarone
  • Benzarone [INN:DCF]

Synonyms

  • 2-Ethyl-3-(4-hydroxybenzoyl)benzofuran
  • 2-Ethyl-3-(p-hydroxybenzoyl)benzofuran
  • 2-Ethyl-3-benzofuranyl p-hydroxyphenyl ketone
  • 2-Ethyl-4'-hydroxy-3-benzoylbenzofuran
  • 5-18-02-00334 (Beilstein Handbook Reference)
  • Benzarona
  • Benzarona [INN-Spanish]
  • Benzarone
  • Benzaronum
  • Benzaronum [INN-Latin]
  • Benzofuran, (2-ethyl-3-(4'-hydroxybenzoyl))
  • BRN 0222901
  • EINECS 216-026-2
  • Ethyl-2 (hydroxy-4 benzoyl)-3 benzofuranne
  • Ethyl-2 (hydroxy-4 benzoyl)-3 benzofuranne [French]
  • Fragivix
  • L 2197
  • L 2197-Labaz
  • Methanone, (2-ethyl-3-benzofuranyl)(4-hydroxyphenyl)-
  • NSC 82134
  • UNII-23ZW4BG89C
  • Vasoc
  • Venagil

Systematic Names

  • 2-Ethyl-3-(4'-hydroxybenzoyl)benzofuran
  • 2-Ethyl-3-benzofuranyl p-hydroxyphenyl ketone
  • Benzarone
  • Ketone, 2-ethyl-3-benzofuranyl p-hydroxyphenyl
  • Methanone, (2-ethyl-3-benzofuranyl)(4-hydroxyphenyl)-

Registry Numbers

CAS Registry Number

  • 1477-19-6

FDA UNII

  • 23ZW4BG89C

System Generated Number

  • 0001477196

Structure Descriptors

InChI

1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3

InChIKey

RFRXIWQYSOIBDI-UHFFFAOYSA-N

Smiles

CCc1c(c2ccccc2o1)C(=O)c3ccc(cc3)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 200mg/kg (200mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 154, Pg. 94, 1965.
mouse LD50 oral > 12gm/kg (12000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 949, 1969.
mouse LD50 subcutaneous > 12gm/kg (12000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 949, 1969.
rat LD50 intraperitoneal 3400mg/kg (3400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 949, 1969.
rat LD50 oral > 12gm/kg (12000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 949, 1969.
rat LD50 subcutaneous > 12gm/kg (12000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 949, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 124.3 deg C   EXP
log P (octanol-water) 4.250 (none)   EST
Atmospheric OH Rate Constant 7.19E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.