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Substance Name: Flumethiazide [INN:BAN]
RN: 148-56-1
UNII: 3PA0CDS0M5
InChIKey: RGUQWGXAYZNLMI-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C8-H6-F3-N3-O4-S2

Molecular Weight

  • 329.278
 
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Names and Synonyms

Name of Substance

  • Flumethazide
  • Flumethiazide [INN:BAN]

Synonyms

  • 6-(Trifluoromethyl)-1,2,4-benzo-thiadiazine-7-sulfonamide 1,1-dioxide
  • 6-(Trifluoromethyl)-1,4,2-benzothiadiazine-7-sulfonamido 1,1-dioxide
  • 6-(Trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 6-Trifluoromethyl-7-sulfamoyl-4H-1,2,4-benzothiadiazine 1,1-dioxide
  • 6-Trifluoromethyl-7-sulfamoyl-4H-1,4,2-benzothiadiazine 1,1-dioxide
  • 6-Trifluoromethyl-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide
  • 6-Trifluoromethyl-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
  • 7-Sulfamoyl-6-trifluoromethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • Ademil
  • Ademol
  • EINECS 205-717-4
  • Fludemil
  • Flumethiazid
  • Flumethiazide
  • Flumethiazidum
  • Flumethiazidum [INN-Latin]
  • Flumetiazid
  • Flumetiazida
  • Flumetiazida [INN-Spanish]
  • Flumetiazide
  • Flumetiazide [DCIT]
  • HSDB 2845
  • NSC 44626
  • Routrax
  • Trifluomethylthiazide
  • Trifluoromethylthiazide
  • UNII-3PA0CDS0M5

Systematic Names

  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide (8CI)(9CI)
  • 4H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
  • 6-(Trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • Flumethiazide

Registry Numbers

CAS Registry Number

  • 148-56-1

FDA UNII

  • 3PA0CDS0M5

System Generated Number

  • 0000148561

Structure Descriptors

InChI

1S/C8H6F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-3H,(H,13,14)(H2,12,15,16)

InChIKey

RGUQWGXAYZNLMI-UHFFFAOYSA-N

Smiles

c12c(cc(S(N)(=O)=O)c(c1)C(F)(F)F)S(N=CN2)(=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1760mg/kg (1760mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961.
mouse LD50 intravenous 910mg/kg (910mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: ATAXIA
Journal of Pharmacology and Experimental Therapeutics. Vol. 128, Pg. 405, 1960.
mouse LD50 oral > 8gm/kg (8000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 0.32 (none)   EXP
Water Solubility 5.00E+04 mg/L 25 EXP
Vapor Pressure 6.25E-11 mm Hg 25 EST
Henry's Law Constant 4.75E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.81E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.