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Substance Name: Pilocarpine nitrate [USP]
RN: 148-72-1
UNII: M20T465H6J
InChIKey: PRZXEPJJHQYOGF-GNAZCLTHSA-N

Classification Codes

  • Cholinergic (Ophthalmic)
  • Mutation Data
  • Reproductive Effect

Molecular Formula

  • C11-H16-N2-O2.H-N-O3

Molecular Weight

  • 271.2713
 
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Names and Synonyms

Name of Substance

  • Pilocarpine nitrate [USP]

Synonyms

  • 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-, mononitrate
  • EINECS 205-723-7
  • P. V. carpine liquifilm
  • Pilagan
  • Pilocarpine mononitrate
  • Pilocarpine nitrate
  • Pilofrin
  • UNII-M20T465H6J

Systematic Names

  • 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S,4R)-, mononitrate
  • 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S,4R)-, nitrate (1:1)
  • 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-, mononitrate
  • Pilocarpine nitrate
  • Pilocarpine, mononitrate

Registry Numbers

CAS Registry Number

  • 148-72-1

FDA UNII

  • M20T465H6J

System Generated Number

  • 0000148721

Molecular Formulas

Molecular Formula

  • C11-H16-N2-O2.H-N-O3

Molecular Formula Fragments

  • C11-H16-N2-O2
  • COMPONENT
  • H-N-O3

Structure Descriptors

InChI

1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1

InChIKey

PRZXEPJJHQYOGF-GNAZCLTHSA-N

Smiles

CC[C@H]1[C@H](COC1=O)Cc2cncn2C.[N+](=O)(O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 345mg/kg (345mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 259, 1931.
rat LD50 oral 911mg/kg (911mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: FLUID INTAKE
Pharmacologist. Vol. 4, Pg. 176, 1962.