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Substance Name: Thiabendazole [USAN:USP]
RN: 148-79-8
UNII: N1Q45E87DT
InChIKey: WJCNZQLZVWNLKY-UHFFFAOYSA-N

Note

  • 2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)

Molecular Formula

  • C10-H7-N3-S

Molecular Weight

  • 201.2523
 

Classification Codes

  • Agricultural Chemical
  • Anthelmintic
  • Anthelmintics
  • Anti-Infective Agents
  • Antiparasitic Agents
  • Fungicide, Bactericide, Wood Preservative
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Names and Synonyms

Name of Substance

  • 1H-Benzimidazole, 2-(4-thiazolyl)-
  • 2-(4-Thiazolyl)benzimidazole
  • Thiabendazole
  • Thiabendazole [USAN:USP]
  • Tiabendazole [INN]

MeSH Heading

  • Thiabendazole

Synonyms

  • 1H-Benzimidazole, 2-(4-thiazolyl)-
  • 2-(1,3-Thiazol-4-yl)benzimidazole
  • 2-(4-Thiazolyl)-1H-benzimidazole
  • 2-(4-Thiazolyl)benzimidazole
  • 2-Thiazole-4-ylbenzimidazole
  • 4-(2-Benzimidazolyl)thiazole
  • AI3-50598
  • APL-luster
  • Benzimidazole, 2-(4-thiazolyl)-
  • Biogard
  • Bioguard
  • Bovizole
  • BRN 0611403
  • Captan T
  • Caswell No. 849A
  • CCRIS 4510
  • Chemviron TK 100
  • Cropasal
  • E-Z-Ex
  • EINECS 205-725-8
  • EPA Pesticide Chemical Code 060101
  • Eprofil
  • Equizole
  • Equizole A
  • G 491
  • Helmindrax octelmin
  • Hokustar HP
  • HSDB 2027
  • Lombristop
  • Mertec
  • Mertect
  • Mertect 160
  • Metasol TK-100
  • Mintesol
  • Mintezol
  • Mintezole
  • Minzolum
  • MK 360
  • MK-360
  • Mycozol
  • Nemapan
  • NSC 525040
  • NSC 90507
  • Omnizole
  • Ormogal
  • Pitrizet
  • Polival
  • Rival
  • RPH
  • RTU Flowable Fungicide
  • Sanaizol 100
  • Sistesan
  • Storite
  • Syntol M100
  • Tbdz
  • TBZ
  • TBZ 60W
  • TBZ-6
  • Tebuzate
  • Tecto 10P
  • Tecto 40F
  • Tecto 60
  • Tecto RPH
  • Testo
  • Thiaben
  • Thiabendazol
  • Thiabendazole
  • Thiabendazole [BSI:ISO]
  • Thiabendazolum
  • Thiabenzole
  • Thibenzol
  • Thibenzole
  • Thibenzole 200
  • Thibenzole ATT
  • Tiabenda
  • Tiabendazol
  • Tiabendazol [INN-Spanish, French]
  • Tiabendazole
  • Tiabendazolum
  • Tiabendazolum [INN-Latin]
  • Tobaz
  • Top form wormer
  • Triasox
  • UNII-N1Q45E87DT

Systematic Names

  • 1H-Benzimidazole, 2-(4-thiazolyl)-
  • Benzimidazole, 2-(4-thiazolyl)-
  • Thiabendazole

Superlist Names

  • 2-(4-Thiazolyl)-1H-benzimidazole
  • 2-(4-Thiazolyl)benzimidazole
  • Thiabendazole

Mixture Name

  • Tresaderm

Registry Numbers

CAS Registry Number

  • 148-79-8

FDA UNII

  • N1Q45E87DT

Other Registry Numbers

  • 1135441-27-8
  • 123242-33-1
  • 145316-67-2
  • 8018-04-0
  • 8027-10-9
  • 8028-27-1
  • 94977-06-7
  • 98002-42-7

System Generated Number

  • 0000148798

Structure Descriptors

InChI

1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)

InChIKey

WJCNZQLZVWNLKY-UHFFFAOYSA-N

Smiles

c1ccc2c(c1)[nH]c(n2)c3cscn3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 4gm/kg (4000mg/kg)   Veterinarno-Meditsinski Nauki. Veterinary Science. Vol. 19(3), Pg. 99, 1982.
domestic animals - goat/sheep LD50 oral 400mg/kg (400mg/kg)   Veterinarno-Meditsinski Nauki. Veterinary Science. Vol. 19(3), Pg. 99, 1982.
man TDLo oral 47619ug/kg/1D (47.619mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pediatrics. Vol. 102, Pg. 317, 1983.
mouse LD50 oral 1300mg/kg (1300mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(10), Pg. 28, 1990.
rabbit LD50 oral 3850mg/kg (3850mg/kg)   "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
rat LD50 oral 2080mg/kg (2080mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 300 deg C   EXP
pKa Dissociation Constant 4.64 (none) 25 EXP
log P (octanol-water) 2.47 (none)   EXP
Water Solubility 50 mg/L 25 EXP
Vapor Pressure 4.00E-09 mm Hg 25 EXP
Henry's Law Constant 2.12E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.50E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.