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Substance Name: Thiabendazole [USAN:USP]
RN: 148-79-8
UNII: N1Q45E87DT
InChIKey: WJCNZQLZVWNLKY-UHFFFAOYSA-N
Note
- 2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)
Molecular Formula
- C10-H7-N3-S
Molecular Weight
- 201.2523
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Agricultural Chemical
- Anthelmintic
- Anthelmintics
- Anti-Infective Agents
- Antiparasitic Agents
- Fungicide, Bactericide, Wood Preservative
- Human Data
- Mutation Data
- Reproductive Effect
- Tumor Data
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Names and Synonyms
Name of Substance
- 1H-Benzimidazole, 2-(4-thiazolyl)-
- 2-(4-Thiazolyl)benzimidazole
- Thiabendazole
- Thiabendazole [USAN:USP]
- Tiabendazole [INN]
MeSH Heading
- Thiabendazole
Synonyms
- 1H-Benzimidazole, 2-(4-thiazolyl)-
- 2-(1,3-Thiazol-4-yl)benzimidazole
- 2-(4-Thiazolyl)-1H-benzimidazole
- 2-(4-Thiazolyl)benzimidazole
- 2-Thiazole-4-ylbenzimidazole
- 4-(2-Benzimidazolyl)thiazole
- AI3-50598
- APL-luster
- Benzimidazole, 2-(4-thiazolyl)-
- Biogard
- Bioguard
- Bovizole
- BRN 0611403
- Captan T
- Caswell No. 849A
- CCRIS 4510
- Chemviron TK 100
- Cropasal
- E-Z-Ex
- EINECS 205-725-8
- EPA Pesticide Chemical Code 060101
- Eprofil
- Equizole
- Equizole A
- G 491
- Helmindrax octelmin
- Hokustar HP
- HSDB 2027
- Lombristop
- Mertec
- Mertect
- Mertect 160
- Metasol TK-100
- Mintesol
- Mintezol
- Mintezole
- Minzolum
- MK 360
- MK-360
- Mycozol
- Nemapan
- NSC 525040
- NSC 90507
- Omnizole
- Ormogal
- Pitrizet
- Polival
- Rival
- RPH
- RTU Flowable Fungicide
- Sanaizol 100
- Sistesan
- Storite
- Syntol M100
- Tbdz
- TBZ
- TBZ 60W
- TBZ-6
- Tebuzate
- Tecto 10P
- Tecto 40F
- Tecto 60
- Tecto RPH
- Testo
- Thiaben
- Thiabendazol
- Thiabendazole
- Thiabendazole [BSI:ISO]
- Thiabendazolum
- Thiabenzole
- Thibenzol
- Thibenzole
- Thibenzole 200
- Thibenzole ATT
- Tiabenda
- Tiabendazol
- Tiabendazol [INN-Spanish, French]
- Tiabendazole
- Tiabendazolum
- Tiabendazolum [INN-Latin]
- Tobaz
- Top form wormer
- Triasox
- UNII-N1Q45E87DT
Systematic Names
- 1H-Benzimidazole, 2-(4-thiazolyl)-
- Benzimidazole, 2-(4-thiazolyl)-
- Thiabendazole
Superlist Names
- 2-(4-Thiazolyl)-1H-benzimidazole
- 2-(4-Thiazolyl)benzimidazole
- Thiabendazole
Mixture Name
- Tresaderm
Registry Numbers
CAS Registry Number
- 148-79-8
FDA UNII
- N1Q45E87DT
Other Registry Numbers
- 1135441-27-8
- 123242-33-1
- 145316-67-2
- 8018-04-0
- 8027-10-9
- 8028-27-1
- 94977-06-7
- 98002-42-7
System Generated Number
- 0000148798
Structure Descriptors
InChI
InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)InChIKey
WJCNZQLZVWNLKY-UHFFFAOYSA-NSmiles
c1ccc2[nH]c(nc2c1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
chicken | LD50 | oral | 4gm/kg (4000mg/kg) | Veterinarno-Meditsinski Nauki. Veterinary Science. Vol. 19(3), Pg. 99, 1982. | |
domestic animals - goat/sheep | LD50 | oral | 400mg/kg (400mg/kg) | Veterinarno-Meditsinski Nauki. Veterinary Science. Vol. 19(3), Pg. 99, 1982. | |
man | TDLo | oral | 47619ug/kg/1D (47.619mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pediatrics. Vol. 102, Pg. 317, 1983. |
mouse | LD50 | oral | 1300mg/kg (1300mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(10), Pg. 28, 1990. | |
rabbit | LD50 | oral | 3850mg/kg (3850mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. | |
rat | LD50 | oral | 2080mg/kg (2080mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 300 | deg C | EXP | |
pKa Dissociation Constant | 4.64 | (none) | 25 | EXP |
log P (octanol-water) | 2.47 | (none) | EXP | |
Water Solubility | 50 | mg/L | 25 | EXP |
Vapor Pressure | 4.00E-09 | mm Hg | 25 | EXP |
Henry's Law Constant | 2.12E-11 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 6.50E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.